Rent lowering gunfire cus apparently it's not clear enough: if you like generative ai, use generative ai, or support generative ai?
Fuck off. You're not wanted here.
macklin celebrini has autism

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Lint Roller? I Barely Know Her
YOU ARE THE REASON
Cosmic Funnies
$LAYYYTER
Xuebing Du
Jules of Nature
Three Goblin Art
DEAR READER
we're not kids anymore.
One Nice Bug Per Day
I'd rather be in outer space 🛸
ojovivo
noise dept.

@theartofmadeline

izzy's playlists!

shark vs the universe
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@thesuspiciousorange
Rent lowering gunfire cus apparently it's not clear enough: if you like generative ai, use generative ai, or support generative ai?
Fuck off. You're not wanted here.

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Oh! The intimacy of adopting each other’s vocabulary.
are you guys hearing about this dude working to developing a vaccine for cats that he's hoping would like. theoretically double their lifespans?
turns out i wasn't making that up, his name is Dr. Toru Miyazaki! he also wrote a book called "The Day Cats Live To Be Thirty", so cats are kind of his thing.
apparently, cats' kidneys tend to be the thing that takes them down, something about their bodies being unable to self-clean their kidneys, and the vaccine is supposed revitalize the body's ability to do just that. It would be very VERY fucking cool to have cats suddenly reaching 30 years of age be the normal thing.
As they age, almost all cats develop kidney disease, from which they eventually die. Just as in humans, kidney disease i
Dr. Toru Miyazaki’s AIM injection for cat kidney disease enters trials in 2025, aiming for a 2027 release. Greycoat Research supports the sc
whoa wait i actually read the articles and it's so much cooler than just that!!
dude cracked the case about WHY kidneys fail, across the board as far as i can tell. turns out there's a specific molecule whose job it is to attach to waste and signal macrophages to come eat it. it remains inactive in cats for some reason, but the molecule is still there. basically what he's done is found the switch to activate them. this will be profound not only for our domestic babies, but for big cats too - especially cheetahs!
although his research was focused on cats, it's already being used to develop drugs for humans too!
on top of that, since these molecules are tags for waste, this could also dramatically lower the rate of fatty liver disease, liver cancer, urinary crystals, rheumatoid arthritis, and even some neurological cases! like, they're hoping it may have an impact on parkinson's and alzheimers, but it DOES have an impact on stroke recovery. like. holy shit.
furthermore, he's insisting that the feline drug be affordable if and when it rolls out onto the market. he wants this to be something anyone can get for their cat!! idk how much sway he'll have over the human drug, but hopefully enough that it, too, won't be that expensive.
annnnnd in his research that he's still doing for the human side of things, he's found a potential link between this molecule and estrogen. in the 20,000 samples he's tested, women between ages 10 and 29 had the highest amount of this molecule present in their blood (a higher amount means Something Fucky is going on, essentially. There's a higher amount of waste the body is trying to clean out) but it drops down to be almost equal amongst men and women after menopause. it hasn't been looked into yet, but fuck, just the fact it's noted and known and probably WILL be looked into soon??? imagine if this is what leads to figuring out all the various ways the ovaries and uterus fucks with people and how to fix it. or even like, maybe there's something about estrogen that makes it work better. who knows! but it's rad the link is there to be researched :D
man just think, not only could our kitties start living longer, healthier lives, but just maybe dialysis will become as rare and obsolete as the iron lung is for people. what a badass Dr. Toru is!
"But I don't want to turn people into dinosaurs. I wanna cure kittie kidneys!"
Update: So they have done clinical trials and have submitted it for approval as of april 2026. They are expecting it to be available late 2026/early 2027
The AIM protein drug for feline chronic kidney disease has been submitted for approval in Japan (April 2026). We break down clinical trial d
As for the study itself, the 360 day follow up on stage 3 kidney failure kitties showed that the control had a survival rate of about 20%, while the test group had a survival rate of 80%
New 2026 study: AIM protein boosts cat kidney disease survival from 20% to 80%. Discover how this scientific breakthrough is changing the fu
Our cat Scout is in the early stages of kidney disease. This might be available in time to save her!
developers moving all their bug tracking and suggestion management to discord is like if you could only access customer support if you joined a facebook group. we need to start shaming people who use discords as a replacement for an actual proper repository

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Today's bug thing is this pair of horseshoe crab earrings from Bamboo Jewelry!
A cat is a machine that turns proteins into violence.
#Helios was declawed by his former owners so he doesn't just slap things he dislikes like most cats#he really only feels confident in hissing at them#Especially because a lot of the thing he doesn't like are bugs and those are sharp sometimes :(#Selene has figured this out and now when she hears him hiss she sprints over the kill the fuck out of the bug#Helios has learned she will do this so he'll hiss at stuff louder and louder until she hears him#A nervous old man and his emotional support homicidal maniac tags by @gallusrostromegalus
I couldn't reblog without the tags because the context is hilarious
A Nervous Old Man (right) and his Emotional Support Violence Machine (Left)
Yes, he is more than twice her size. Yes, he is five times her age. Yes, he cries like a big baby until she kills Unacceptable Scary Things (earwigs) for him.
the strongest bond is probably pad wings to themselves. the weakest is probably pad wings to your underwear
STOP SCROLLING
Your life ends in the wasteland.
there’s a japanese radish just below this post but you can’t reach it

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収穫祭
2015年、長屋門公園。
立派な大根がリアカーに積まれていた。ここで育てたものだろうか。
Emergency cleaning: Unfuck your whole house in the shortest time possible
So, your landlord/parents/home inspector/favorite movie star is dropping by, and your place is a disaster. You don’t have much time to clean it up. You’re in emergency mode. Let’s get started.
Don’t panic. Panic leads to fear, fear leads to procrastination, procrastination leads to the dark side. You can do this, but you have to stay calm.
Unlike maintenance cleaning, we’re not looking to completely unfuck one space at a time. Instead, we want to decrease the overall mess in stages, spread evenly across the whole area that we’re concerned about. If you think your home is at Level 10 filth, we want to bring the whole thing down to a Level 9, and then down from there. One really clean spot in an otherwise messy home is not going to be helpful here.
Get prepared. You’ll want to shut the computer down (or turn the modem off if you need your computer to play music). Trust me. Get your music going. Gather up trash bags, your vacuum and mop, some rags or paper towel, sponges, and other cleaning supplies. Use what you have on hand. Don’t get distracted running to the store and spending an hour browsing cleaning supplies. A multi-purpose cleaning concentrate or a jug of vinegar will be just fine.
Breaks are very important. Depending on your time constraints, work in 20/10s (20 minutes working, 10-minute break) or 45/15s. But take breaks because otherwise you’re marathoning, and marathon cleaning is no one’s friend. Keep hydrated, don’t forget to eat, and check in with yourself frequently to make sure you’re physically doing OK.
Make your bed. This will be your home base if you get overwhelmed or need somewhere clear to take a break.
Start with the garbage. Going from room to room, throw out anything that is obvious trash. Once you fill a bag, take it out. Repeat as many times as necessary.
Move on to dishes. Gather the dishes from all over your house and bring them to the kitchen. If you can, start them soaking in a sink of hot, soapy water or start loading the dishwasher. After the dishes are all in one place, spend one 20/10 getting started getting them under control.
Now it’s time for your flat surfaces. Countertops, tables, dresser tops, etc. Clear them off and wipe them down. Don’t get distracted in too much sorting and organizing. We’re in crisis mode here. There will be time to get in-depth once this is all done. The same applies to cabinets and closets. Unless you have reason to believe people will be opening closed doors, leave these alone for now.
Attack the floordrobe and shoe pile. Get your clothes either put away or in the hamper. Start a load of laundry if you need to, but keep in mind that laundry and dishes have three steps: wash, dry, and put it away, goddammit!
Get random stuff up off the floors. If something is trash-worthy, throw it away now rather than just move it around a bunch of times. Otherwise, put stuff where it belongs.
Take another 20/10 or 45/15 to catch up on more dishes, if needed.
Head into the bathroom. Pour some cleaner in the toilet bowl, fill the sink with hot water and cleaner, and either spray the tub and shower with cleaner, or fill the tub up with some hot water and add cleaner and let it soak. Put everything away that’s out and shouldn’t be, clean the mirror, counters, and toilet seat. Sweep or dry mop the floor. Wipe down the sink and tub/shower, and give the toilet bowl a scrub. Mop the floor.
Sweep and mop the kitchen floor.
Vacuum everything you can, and sweep everything you can’t.
Walk outside of your house (don’t lock yourself out, please). Walk back in and see what catches your eye first. Go and deal with that.
If you’re being inspected or your landlord is coming in for repairs, spend time on whatever area they’ll be focusing on.
Give the whole place one more once-over and pay attention to anything you’ve missed so far.
It’s an old trick, but if your place is a little funky-smelling, put a pan of water on the stove on low heat and add some citrus or cinnamon or vanilla. Don’t leave it unattended or forget about it.
Take a shower, put on something clean, and eat something.
You can do this. It’s overwhelming, yes, but it is not impossible. You just need to do it. You have a list. You have directions. You have a whole bunch of Internet strangers who have been there before and who are cheering you on. You can do this, but you need to get started.
Why are you still here? GO. START. NOW.
the number of times in my past that I desperately wanted/needed someone to sit me down and tell me this stuff. I will never get back the hours and hours lost to headless-chicken mode, but it’s nice to know that in the last year I’ve learned so many coping mechanisms :D
the removal of physical media is not the inevitable progression of improving tech, its like the removal of the 3.5mm jack: purely a result of profit physical games still account for about 1/5th of all sales of video games
but by only selling digital games sony can be the ultimate arbiter of their price. they can stop you lending games and force another sale instead. they can stop the sale of second hand games and keep prices artificially high. they can set any price they want and that will be your only option.
Not enough people are understanding the funniest part of this. Everyone's making colour theory jokes but the dad is colour blind. The most common colour blindness is red green colour blindness. It's the one where red and green look relatively the same shade of brown.
Everyone's talking about the blood carpet. Dad is seeing a carpet absolutely blasted with shit.

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some people like to get mad at disability benefits because they think its unfair people who dont work get a payout from the government while they have to work 50 hours at the human suffering factory every week. but if you tell them "yeah that sucks i think you should also get a universal allowance and not have to work 50 hours at the human suffering factory every week" thats apparently the wrong answer.
I'm sorry I keep posting my tiktok comments but please. What does this mean. What do people THINK shipping is for anymore???
AO3 authors in the lab creating ships purely for research purposes:
Creating ships for the tax write-off
Creating ships to get that fucking whale.
creating ships to wedge into the Suez canal and disrupt global shipping