Been messing around in Rogue Legacy 2 to try and find different ways to tackle the game to keep it interesting outside of just the burdens and cranking up the thread, heres a few that have been fun concepts
-Teleporter Malfunction: All the teleporters throughout Genesis have gone on the fritz and stopped allowing people to enter through them. The sheer exception is the one by Mehujael's Memorial. Nothing else is different other then backtracking
-Shuffled: Roll a d6 each time you begin a biome. that roll dictates where and who you have to kill next (1 is Agartha/Lamech, 2 is Axis Mundi/Crew, etc.)
-Progressive Upgrades: Start the thread with no armour equipped. Each time you die, you may upgrade one piece to the next tier (nothing to leather, going down the list). Play until you reach your usual build or can clear the thread
-Boss Rush: Full clear all of Genesis except for the minibosses and the estuaries. Once everything is cleared, slay the minibosses, then the estuaries in order. See how many you can take down before one of them ends you