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Regorafenib - an inhibitor of tyrosine kinase (VEGFR - TIE2) for the treatment of metastatic colorectal cancer, unresectable hepatocellular carcinoma, and gastrointestinal stromal tumours. Its structure is closely related sorafenib with a Florine replacement.
Sorafenib - inhibitor of tyrosine protein kinases (VEGFR, PDGFR, and Raf kinases) for the treatment of advanced renal cell carcinoma, hepatocellular carcinoma, and radioactive iodine resistant advanced thyroid carcinoma.
Antiangiogenic Cancer Therapy
C O N T E N T S:
KEY TOPICS
Data from late-stage clinical trials support the role of antiangiogenic agents in cancer therapy and the significant role that VEGF plays in angiogenesis.(More…)
POSSIBLY USEFUL
A phase III trial of the currently marketed monoclonal antibody to VEGF-A (referred to as VEGF), bevacizumab (Avastin), added to conventional cytotoxic chemotherapy showed greater survival in…
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