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Emupertinib
Emupertinib CAS 2472802-77-8 MFC30H26N8O MW514.6 g/mol 2-Pyrazinecarboxamide, N-[4-[4-amino-6-ethynyl-5-(3-quinolinyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]bicyclo[2.2.1]hept-1-yl]-5-methyl- N-{4-[4-amino-6-ethynyl-5-(quinolin-3-yl)-7Hpyrrolo[2,3-d]pyrimidin-7-yl]bicyclo[2.2.1]heptan-1-yl}-5-methylpyrazine-2-carboxamideepidermal growth factor receptor tyrosine kinase, inhibitor, antineoplastic,…
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What's the best way to tell the difference between a red tabby with the silver gene and one that's dilute? I have two red tabby girls who aren't "just" red, but they're also two different shades of red-ish. I'm pretty sure at least one of them is simply dilute red, but I wonder about the other one, and why they look different.
It's hard to get a picture of them next to each other because they don't really get along (in the second picture I think they were investigating a piece of dropped food I think)
The little old lady that's a bit less stripey is Babycakes, and the big fat one is Ginger. Ginger is a bit lighter compared to the reds my friends have.
Best way to tell the difference between a cream (dilute red) and a cameo (red silver) cat is the base of the hairs. Cameo cats will have the bases of the hairs be extremely pale and white. If you part their fur, the color of the fur at the base of their skin should be white. Cream cats do not have this, because it's a side effect of inhibitor.
That being said, Babycakes is a cream mackerel tabby, and Ginger is a cameo mackerel tabby with white.
Sneak out with me,
Find the space for us to play
The parts you want to look at
Feel the parts you can’t
Show me
I’m not scared, are you?
any idea what my Most Handsomest Boy Ever maccabee could be? i usually just refer to him as "black" but he has these little stripes on his tail which i don't think ive ever seen before.
(also the gray on his paw is just because he's an Old Man. don't know why it's only on the one paw. he's just special)
Macabee seems to be a black self smoke!
Smoke causes very distinct "ghost striping" as seen on your Most Handsomest Boy Ever's face and tail, alongside causing the bases of the hairs to be white (as seen in a few images shown). What a cutie!
This is Patsy. The vet asked what colour(s) she was before her first appointment, and all I could think to say was, "most of them?"
ANOTHER SMOKE TORTOISESHELL HAS HIT THE INBOX!!!!! Patsy is such a darling black smoke tortoiseshell with low white! I absolutely adore looking at these cats, the mixture of smoke ghost patterning and cameo tortoiseshell stripes is just, MWAH chefs kiss.
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I can't find a clear answer on how the silver/melanin inhibitor gene interacts with the red gene vs black alleles- if I have an agouti tortoiseshell cat (torbie) that happens to have the melanin suppressing allele, would she be entirely silver? Or would there still be a difference in the patches which would otherwise be red or black tabby? Hopefully this makes sense 😭
This might be a bit of an oversimplification, but imagine it like if the tabby background is silvery-white everywhere, and the stripes are respectively black-based or red-based depending on the tortie pattern.
Meet my cat Shici, he's very affectionate and a bit jelous
He's like a living plush, he has some different spots of mane/cat hairs (idk the name of it) when it's sunny his mane become more brownish and he has a few white/grey spots.
Can you help me with identify his phenotypes?
Shici seems to be a longhaired black smoke!
The brown and white you're seeing is because of this; the blacker parts turn browner in the sun, and the white that back the hairs on inhibitor-active cats can become more visible as a cat ages.
BRAF inhibitor resistance in melanoma: from resistance mechanisms to therapeutic innovations - Research
BRAF inhibitors (BRAFi) have transformed the treatment of BRAF mutant melanoma, but inherent and acquired resistance remains a major barrier to curative outcomes. Resistance arises from interconnected mechanisms: genetic alterations reactivating the MAPK pathway or bypass cascades (e.g., PI3K/AKT/RTK), epigenetic modulation, metabolic reprogramming, and the tumor microenvironment (TME)…
