#upregulation

This flu still has me congested and my brain is still fried, but the tastebuds work again. (If you happen to be in the #Alhambra area before February, stop by @grillemall and get their Burger Of The Month. Hopefully, with enough support, they'll add it to their permanent menu!) #Lunch #RainyDay #GourmetBurger is #Garlic-#Spinach-#Artichoke #Dip, #GarlicAioli, #GarlicBacon, #Cheddar, #GarlicChips, on #GarlicButter #Buns. #comfortfood #cheatmeal #carbcycling #WhiteBloodCell #upregulation

a. State of progressively decreasing responsiveness to same does of drug b. Three types       i. Metabolic—liver makes more enzymes due to influx of drug intake       ii. Cellular—up/down regulation of receptors       iii. Behavioral conditioning—independent of the above when given with drug cues           1. Ex: goes to bar w/friends and need more alcohol every time to get drunk; when home and drink w/family (and rarely drink with them) need less alcohol to get drunk