#tocotrienols

As a dermatologist, I often remind patients that the skin is not only our largest organ but also a mirror of our internal health. Every day, our skin faces oxidative stress from ultraviolet (UV) radiation, environmental pollutants, and chronic inflammation. Over time, these stressors accelerate skin ageing, trigger pigmentation, and increase the risk of conditions such as eczema and delayed wound…

Vitamin E is a powerful antioxidant that protects cells from oxidative damage, reducing the risk of chronic diseases.

The vitamin E complex includes tocopherols and tocotrienols, each offering unique health benefits.

Vitamin E supports cardiovascular health by lowering cholesterol, reducing inflammation, and maintaining arterial health.

It enhances skin health, promoting hydration, elasticity, and reducing signs of aging.

Vitamin E also offers neuroprotective benefits, supporting brain health and potentially preventing neurodegenerative diseases.

Introduction

Vitamin E is an essential nutrient known for its antioxidant properties and its role in protecting the body from oxidative stress.

This fat-soluble vitamin is a complex made up of two main types of compounds: tocopherols and tocotrienols.

Both play significant roles in maintaining health, though they offer slightly different benefits.

Ensuring an adequate intake of vitamin E through diet or supplementation can have a profound impact on overall wellness.

Antioxidant Properties of Vitamin E

Vitamin E’s primary function is as an antioxidant, which helps protect cells from oxidative damage caused by free radicals.

Free radicals are unstable molecules that can damage cells, leading to inflammation, aging, and chronic diseases such as heart disease and cancer.

Vitamin E neutralizes these free radicals, reducing the oxidative stress that contributes to these health issues.

The antioxidant potency of vitamin E is well-documented. Tocotrienols, in particular, have shown superior antioxidant activity in certain studies compared to tocopherols, making them a valuable component of the vitamin E complex.

Cardiovascular Health Benefits

Vitamin E supports heart health, primarily through its effects on cholesterol and inflammation. Tocotrienols are particularly effective at lowering LDL cholesterol.

Beyond cholesterol management, vitamin E helps maintain arterial health by preventing the oxidation of LDL cholesterol, a process that can lead to arterial damage and cardiovascular complications.

Additionally, vitamin E’s anti-inflammatory properties further support cardiovascular health by reducing inflammation-related risks.

Skin Health and Anti-Aging Effects

Vitamin E is well-known for its benefits to skin health. It supports skin hydration by maintaining the skin’s lipid barrier, which helps retain moisture.

This leads to improved skin elasticity and a reduction in the appearance of fine lines and wrinkles. Vitamin E is also effective in treating skin conditions like eczema and psoriasis.

Its antioxidant properties protect the skin from damage caused by environmental factors such as UV rays and pollution, which can accelerate aging.

Whether applied topically or consumed through diet, vitamin E can help keep your skin looking healthy and youthful.

Neuroprotective Benefits

Vitamin E’s neuroprotective properties make it a valuable nutrient for brain health. It helps protect neurons from oxidative stress and inflammation, which are key factors in cognitive decline and neurodegenerative diseases like Alzheimer’s and Parkinson’s.

Studies have shown that adequate intake of vitamin E can slow down cognitive decline, support memory, and potentially reduce the risk of developing neurodegenerative conditions.

Tocotrienols, in particular, have shown promising results in protecting the brain from the effects of aging and stress.

Immune System Support

A healthy immune system relies on sufficient levels of vitamin E. This nutrient boosts the body’s natural defenses by enhancing the function of immune cells, making it easier for the body to fight off infections.

Vitamin E has been shown to reduce the severity and duration of infections, particularly in individuals with compromised immune systems.

Both tocopherols and tocotrienols contribute to immune health, though they may impact different aspects of immune function.

Ensuring adequate vitamin E intake can be particularly beneficial during illness or recovery periods.

Bone Health and Metabolic Benefits

Vitamin E also supports bone health by contributing to bone density and reducing the risk of osteoporosis. This is especially important as we age, as bone density naturally decreases, increasing the risk of fractures.

Vitamin E helps mitigate this risk by supporting bone health at a cellular level.

In terms of metabolic health, vitamin E has been shown to improve insulin sensitivity and help regulate blood sugar levels. This can be beneficial for those managing diabetes or metabolic syndrome, as well as for general weight management.

Sources of Vitamin E

Including both tocopherols and tocotrienols in your diet is important for reaping the full benefits of vitamin E.

Foods rich in tocopherols include nuts, seeds, spinach, while tocotrienols are found in palm oil, rice bran oil, and wheat germ oil.

Supplements are a good option for those who may not get enough vitamin E from food sources alone.

Choose a supplement that includes both tocopherols and tocotrienols to ensure a balanced intake of this vital nutrient.

Credit – amazon.com

Credit – amazon.com

Credit – amazon.com

Consult with a healthcare provider before starting any new supplementation.

Conclusion

Vitamin E complex offers a wide range of health benefits, from its powerful antioxidant properties to its roles in supporting cardiovascular, skin, brain, and immune health. Ensuring an adequate intake of both tocopherols and tocotrienols through diet or supplements can help protect against chronic diseases, promote longevity, and enhance overall well-being.

FAQs

What is the difference between tocopherols and tocotrienols?

Tocopherols and tocotrienols are both forms of vitamin E, but they differ in their chemical structure and some of their health benefits. Tocotrienols generally have stronger antioxidant properties and are more effective in certain health applications.

How much vitamin E should I take daily for optimal health?

The recommended daily allowance (RDA) for vitamin E varies by age and gender, but for most adults, it is around 15 mg. However, individual needs may vary, so consulting a healthcare provider is advisable.

Can vitamin E help with skin conditions like eczema?

Yes, vitamin E is beneficial for skin health and can help manage conditions like eczema by reducing inflammation and improving skin hydration.

Are there any side effects of taking vitamin E supplements?

Vitamin E is generally safe when taken at recommended doses, but high doses can cause side effects such as nausea, diarrhea, and increased risk of bleeding. It’s important to follow dosage guidelines.

Can I get enough vitamin E from food alone, or do I need supplements?

Many people can get enough vitamin E from a balanced diet rich in nuts, seeds, and green leafy vegetables. However, those with specific health needs or dietary restrictions might benefit from supplementation.

Research

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Barberger-Gateau, P. et al. (2007). "Delaying Alzheimer's disease with antioxidants: a randomized controlled trial." Archives of Neurology, 64(12), 1657-1662.

Chin, S.F. et al. (2010). "Effect of a tocotrienol-rich fraction on exercise endurance capacity of patients with coronary artery disease." Malaysian Journal of Medical Sciences, 17(3), 9-18.

Das, S. et al. (1995). "Isolation and identification of phenolic antioxidants in Triticum aestivum L." Journal of Agricultural and Food Chemistry, 43(6), 1602-1605.

Das, S. et al. (2008). "Antioxidative, anti-inflammatory, and antimutagenic activities of annatto (Bixa orellana L.) extracts." Journal of Agricultural and Food Chemistry, 56(10), 3905-3913.

Fu, J.-Y., Che, H.-L., Tan, D.M.-Y. and Teng, K.-T., 2014. Bioavailability of tocotrienols: evidence in human studies. Nutrition & Metabolism, [online] 11(1), p.5. https://doi.org/10.1186/1743-7075-11-5.

Hickey, M.C. et al. (2013). "A pre-clinical study of (−)-epigallocatechin-3-gallate, a naturally occurring anti-inflammatory agent of green tea in the prevention and treatment of collagen-induced arthritis." British Journal of Nutrition, 109(8), 1453-1462.

Khan, M.I. et al. (2018). "Mechanism underlying anti-inflammatory response of lipid soluble fraction of elaeis guineensis (oil palm) leaves." Lipids in Health and Disease, 17(1), 300.

Magosso, E. et al. (2016). "Tocotrienols for normalisation of hepatic echogenic response in nonalcoholic fatty liver: a randomised placebo-controlled clinical trial." Nutrition Journal, 15, 40.

Mat Yusof, Y. et al. (2015). "Tocotrienols and breast cancer: the evidence to date." Genes & Nutrition, 10(5), 459.

Meganathan, P., & Fu, J. (2016). Biological Properties of Tocotrienols: Evidence in Human Studies. International Journal of Molecular Sciences, 17(11), 1682. https://doi.org/10.3390/ijms17111682

Miyazawa, T. et al. (2002). "Antioxidative and antiatherogenic effects of palm oil-derived α-tocotrienol in diabetic swine." Journal of Nutrition, 132(3), 522-528.

Nesaretnam, K. et al. (2003). "Tocotrienols: potent neuroprotective agents in vitro and in vivo, and an insight into their mechanisms of action." Clinical Science, 104(4), 447-458.

Packer, L. et al. (2001). "Molecular Aspects of Medicine." Amsterdam, Elsevier.

Pamudji, I.A. et al. (2014). "Tocotrienol-rich fraction protects against UVB-induced skin damage in hairless mice." Journal of Photochemistry and Photobiology B: Biology, 140, 150-157.

Pearce, B.C. et al. (1998). "Inhibition of cholesterol synthesis by novel geranylgeranylpyrophosphate synthase inhibitors." Journal of Lipid Research, 39(11), 2283-2290.

Qureshi, A.A. et al. (1996). "Synergistic effect of tocotrienol-rich fraction (TRF(25)) of rice bran and lovastatin on lipid parameters in cholesterol-fed chickens." Journal of Nutritional Biochemistry, 7(11), 610-615.

Qureshi, A.A. et al. (2020). "Tocotrienols: A Family of Vitamin E with Multiple Health Benefits." Nutrients, 12(7), 2049.

Sen, C. K., Khanna, S., & Roy, S. (2007). Tocotrienols in health and disease: The other half of the natural vitamin E family. Molecular Aspects of Medicine, 28(5-6), 692. https://doi.org/10.1016/j.mam.2007.03.001

Sen, C.K. et al. (2011). "Handbook of Oxidants and Antioxidants in Exercise." Amsterdam, Elsevier.

Shahidi, F., & De Camargo, A. C. (2016). Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits. International Journal of Molecular Sciences, 17(10), 1745. https://doi.org/10.3390/ijms17101745

Siddiqui, R.A. et al. (1997). "Suppression of induced nitric oxide synthase expression by alpha-tocopherol in macrophages." Journal of Leukocyte Biology, 62(6), 791-799.

Tan, B. et al. (2004). "Tocotrienols Synergistically Inhibit Human Breast Cancer Cell Proliferation and Induce Apoptosis." Journal of Nutrition, 134(12), 3196-3201.

Theriault, A. et al. (2009). "Dietary vitamin E and its tocopherols inhibit cell proliferation and induce apoptosis in MDA-MB-231 and MCF-7 human breast cancer cells." Chemistry & Biodiversity, 6(9), 1460-1470.

Tengku Mohamad, T.A. et al. (2017). "Tocotrienol-rich fraction prevents cell cycle arrest and elongates telomere length in senescent human diploid fibroblasts." Oxidative Medicine and Cellular Longevity, 2017, 3203437.

Is Tocotrienol Better Than Vitamin E?

Tocotrienols Vitamin E For Breast Cancer

Tocotrienol is a potent antioxidant and helps prevent oxidative stress which causes breast cancer. Tocotrienols inhibit tumour development by blocking oxidative stress DNA damage. They also suppress the CSC's(Cancer Stem Cells) self-renewal at optimum levels. 

Healthy Liver is a key to living a healthy life. The liver is an important part of the body which is responsible to carry out all the metabolic functioning of the body. It has the ability to regenerate and that is why people suffering from any liver disease can be treated with detoxification and lifestyle changes.

Tocotrienols Vitamin E is the best form of vitamin E for a healthy liver. It has hepatoprotective effects that are very important for the healthy functioning of the body.

Tocotrienol Vitamin E for Non-Alcoholic Fatty Liver Disease (NAFLD)

Liver helps in the digestion of fats effectively. Fatty liver problem occurs when the fat gets oxidized and gets deposited causing fatty liver. Vitamin E Tocotrienol plays an important role in controlling fat deposition and reversing fatty liver issues. Well, we also cannot ignore fats and stop taking them completely. It is important to consume some amount of healthy fat for a healthy nervous system. You can take tocotrienol supplement  in the form of healthy fats for the proper and healthy functioning of the body.

Best Vitamin E Tocotrienols For Cancer Management