HPS5 - Hermansky–Pudlak Syndrome 5 or Biogenesis of Lysosomal Organelles Complex 2 Subunit 2
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes.
Three-spine stickleback
casper
Inheritence: sex-linked recessive.
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Mouse
ruby-eye 2 (five mutations)
haze
maroon
Inheritence: recessive, interaction unknown.
ruby-eye 2 (the black kit is "rescued": injected with a genetic element that replaces the mutated gene)
Cat
pink-eye
Inheritence: recessive.
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Horse
eden white (three mutations)
Inheritence: possibly additive, penetration is not full.
compound heterozygote (EDXW1/EDXW3), heterozygotes (EDXW2/N, EDXW3/N); the "founders" (the horses in whom the alleles were first found). W20 is another, different white spotting gene.
