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Vader Displeased with Readmissions, Delinquent Discharge Summaries
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MED-SURG UNIT, DEATH STAR MEDICAL CENTER, DEATH STAR - We have received word from the Rebel Alliance that Darth Vader has been distracted and displeased by the woeful readmission and length-of-stay metrics reported at last month's staff meeting. Gomerblog has confirmed Death Star h...
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Complement C3 Triggers Malignant Progression of Mesenchymal Subtype Glioma by ShengfuShen,Xun Jin*
Abstract
Patient safety, quality, and efficiency are global issues, therefore hospitals must be able to apply clinical pathways through clinical pathways as the main facilities and infrastructure, especially in services for increasingly acute drug addicts. This study aims to analyze the implementation of clinical pathways for drug rehabilitation program outcomes on 1) clinical quality, 2) cost, 3) readmission, 4) satisfaction, and 5) LOS, at RSJD Atma Husada Mahakam. This type of research uses cross-sectional with observational analytic, data collection through distributing questionnaires to 111 respondents, observation and literature study. The results showed that the clinical quality before and after the implementation of the clinical pathway had a significant effect, but the cost of treatment did not show any significance. There is a positive relationship between readmission and the implementation of clinical pathways, as well as addict satisfaction in the LOS rehabilitation room has a significant effect on treatment time and clinical pathways. A recommendation that the 5 (five) variables mentioned above, apart from being cost-effective, can improve the quality of drug rehabilitation services at RSJD Atma Husada Mahakam Samarinda, so it needs to be maintained
Keywords: Outcome; Quality Clinic; Readmission; Cost, Satisfaction; Length of Stay
Introduction
Glioma is the most common primary intracranial tumor. The World Health Organization (WHO) classification of tumors of the central nervous system is divided into Ⅰ-Ⅳ glioma grade [1]. Among them, the most invasive tumor is glioblastoma (GBM), WHO IV grade, which is characterized by uncontrolled cell proliferation, diffuse infiltration, tendency to necrosis, strong angiogenesis, and chemoradiotherapy resistance [2,3]. At the transcriptome level, GBM can be divided into three subtypes: proneural (PN) ,classical (CL) and mesenchymal (MES)[4,5]. However, different subtypes of glioma prefer different tumor microenvironments [6]. Among them, MES subtype glioma is highly enriched in necrosis area with hypoxia and strong inflammation [7,8]. Clinically, MES subtype glioma is very difficult to treat, due to its strong chemoradiotherapy resistance [9,10]. However, the relationship between chemoradiotherapy resistance and inflammation is unclear. In fact, most inflammation is triggered by a strong immune response [11,12]. As an important part of the innate immune response, complement also plays an important role [13].
Complement has been described as an important factor in the pathogenesis of many central nervous system diseases including infectious, autoimmune and degenerative disorders [14-16]. Complement overexpression is associated with acute brain injury and chronic neurodegenerative diseases including Alzheimer’s disease [17, 18] and Huntington’s disease [19]. Furthermore, C3 serves as a stage-biomarker of Alzheimer’s disease in cerebrospinal fluid (CSF) [20]. Recently, complement C3 was found to be upregulated in all models of meningeal metastasis, and proved to be essential for the growth of cancer in meningea [21]. However, The role of complement C3 in glioma is not certain. In this study, we firstly found that complement C3 is associated with poor prognosis in glioma patients. Then, C3 may regulate malignant progression of glioma through NF-kB and JAK-STAT signaling pathways. Finally,C3 is highly expressed in MES subtype glioma and enhances its chemoradiotherapy resistance.
Material and Methods
Data Mining from Public Databases
First, we searched ONCOMINE databases (https://www.oncomine.org/resource/main.html) to observe the expression of C3 in different tumors. We searched an online website Gene Expression Profiling Interactive Analysis (GEPIA) (http://gepia.cancer-pku.cn/index.html) to investigate the differential expression of C3 mRNA in glioma tissues and normal tissues. Then, we downloaded the clinical and transcriptional data of glioma patients from TCGA, CGGA, Rembrandt and Gravendeel database (http://gliovis.bioinfo.cnio.es/). The immunohistochemistry data was downloaded in The Human Protein Atlas(https://www.proteinatlas.org/).
GO and KEGG Pathway Enrichment Analysis
Pathway enrichment analysis was performed on DAVID (https://david.ncifcrf.gov/).Biological significance of differentially expressed genes was explored by GO enrichment analysis including biological process, cellular component and molecular function. KEGG pathway enrichment analysis of differentially expressed genes was performed to explore the critical pathways closely related to C3 up-regulated malignant progression of glioma. We used the “ggplot2” package and “pathview” package (version 1.24.0), which were based on R software to do the visualization of the GO and KEGG signal pathway.
Statistical analysis
The data were analyzed using GraphPad Prism (version 8.0) and R software (version 4.0). Low and high C3 expression groups were established based on the median C3 mRNA expression value in datasets. The relationship between C3 expression and a series of categorical variables were analyzed by t-test or Fisher exact-tests. Moreover, we employed a multivariate Cox regression model to probe whether C3 expression was an independent prognostic indicator in glioma patients. Kaplan-Meier curves were utilized to evaluate the prognostic significance of C3. P-values less than 0.05 on both sides were statistically significant.
Result
Complement C3 Plays an Important Role in the Malignant Progression of Glioma
In the ONCOMINE database, the complement C3 is highly expressed in most tumors (Figure 1A). We use GEPIA to analyze the mean expression levels of complement C3 in tumor tissue and paired normal tissue, and find that complement C3 is high in glioma (Figure 1B). To explore the prognostic significance of complement C3 in glioma, we analyze the TCGA-GBMLGG database and found that C3 high expression can promote the malignant progression of glioma (P<0.001)(Figure 1C). The same conclusion is verified in CGGA, Rembrandt and Gravendeel database (Figure 1E-G). We use a multivariate COX regression model to analyze detailed associations between C3 expression and clinical features. As shown in (Table 1), the expression of complement C3 is an independent factor to affect patient survival.
In the TCGA-GBMLGG database, C3 high group and low group do difference analysis, to obtain 1501-regulated genes and 731 down-regulated genes, based on the cut-off criteria (P<0.05 and fold change≥2) (Figure 2A) . The up-regulated genes in the top 200 p-values are selected for GO biological function enrichment analysis. In terms of biological process, C3 up-regulated genes are significantly enriched in the inflammatory reaction and immune response.For cellular components, C3 up-regulated genes are significantly enriched in cell membranes and extracellular matrices. Regarding the molecular function, the up-regulation genes are significantly enriched in cytokine receptor activation (Figure 2B). These significant enrichments can help us further understand the role of C3 in glioma occurrence and progress. Furthermore, KEGG pathway enrichment analysis shows that the C3 up-regulation genes are associated with NF-kB and JAK-STAT signaling pathways (Figure 2C). Similarly, GSEA also reflects that the C3 high expression group up-regulates NF-kB and JAK-STAT signaling pathways (Figure 2D). The KEGG analysis reveals that C3 up-regulated genes increase the expression of the relevant genes of these two signaling pathways, thereby promoting the malignant progression of gliomas (Figure 2E-F). Gene co-expression network is constructed to detect genes showing similar trends (Figure 2G).
Complement C3 Specifically Promotes the Growth of Mesenchymal Subtype Gliomas and Trigger Chemoradiotherapy Resistance
Immunohistochemical staining reveals that C3 is highly expressed in high-grade glioma, especially in area of necrosis (Figure 3A). In the Rembrandt database, C3 mRNA is highly expressed in MES subtype glioma (Figure 3B). C3 high expression and MES subtype correlation signaling pathways are significantly enriched (P<0.01) (Figure 3C). In fact, MES subtype gliomas are highly radiotherapy and chemotherapy resistant. Therefore, we analyze the effect of different treatments on the prognosis of glioma. We found that chemoradiotherapy can significantly prolong the survival of glioma patients (Figure 3D). However, in the group of chemoradiotherapy, C3 high expression might cause chemoradiotherapy resistance in glioma patients and affect their prognosis (Figure 3E).
Discussion
Gliomas account for approximately 80% of primary central nervous system (CNS) malignant tumors, with high invasiveness, recurrence, high mortality and other characteristics [2]. Currently, the standard treatment for glioma is surgery combined with radiotherapy and chemotherapy [22,23]. In fact, due to the deep location of glioma and chemoradiotherapy resistance, the prognosis of patients remains poor [24,25]. Therefore, in response to these difficulties, we need to propose new treatment options.
Studies have shown that patients with MES signatures belong to the poor prognosis subtype and are resistant to standard treatments [26,27]. In this study, we analyzed that C3 high expression causes chemoradiotherapy resistance in MES subtype gliomas. We also found that C3 high expression promotes chemoradiotherapy resistance in gliomas through NF-kB and JAK-STAT signaling pathways. Similarly, a previous study found that a subset of the PN GSCs undergoes differentiation to a MES state [28] in a TNF-a/ NF-kB-dependent manner with an associated enrichment of CD44 subpopulations and radioresistant phenotypes [29,30]. They further show that the MES signature, CD44 expression, and NF-kB activation correlate with lower radiation response and shorter survival in patients [30].
In summary, the expression of C3 is an important factor affecting the chemoradiotherapy resistance of gliomas. Our data shows that C3 high expression may activate NF-kB and JAK-STAT signaling pathway to promote the chemoradiotherapy resistance of glioma, leading to poor prognosis. Therefore, it is a new therapeutic scheme for targeting C3 and associated signaling pathways to inhibit the chemoradiotherapy resistance of gliomas and improve the prognosis of patients.
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Influence of Clinical Pathway Implementation on the Outcome of Drug Rehabilitation Program Services by Jaya Mualimin
Abstract
Patient safety, quality, and efficiency are global issues, therefore hospitals must be able to apply clinical pathways through clinical pathways as the main facilities and infrastructure, especially in services for increasingly acute drug addicts. This study aims to analyze the implementation of clinical pathways for drug rehabilitation program outcomes on 1) clinical quality, 2) cost, 3) readmission, 4) satisfaction, and 5) LOS, at RSJD Atma Husada Mahakam. This type of research uses cross-sectional with observational analytic, data collection through distributing questionnaires to 111 respondents, observation and literature study. The results showed that the clinical quality before and after the implementation of the clinical pathway had a significant effect, but the cost of treatment did not show any significance. There is a positive relationship between readmission and the implementation of clinical pathways, as well as addict satisfaction in the LOS rehabilitation room has a significant effect on treatment time and clinical pathways. A recommendation that the 5 (five) variables mentioned above, apart from being cost-effective, can improve the quality of drug rehabilitation services at RSJD Atma Husada Mahakam Samarinda, so it needs to be maintained
Keywords: Outcome; Quality Clinic; Readmission; Cost, Satisfaction; Length of Stay
Introduction
Drug dependence is a type of chronic recurrent brain disease and must receive therapy and rehabilitation. According to a 2016 BNN survey, the prevalence of drug abuse in East Kalimantan is 3.1% of the population aged 15-49 years. 10% of abusers experiencing health problems need to get medical help. Relapse will affect the quality, quality and patient safety (patient safety). if no preventive measures are taken with organizational policies. The cause of the high number of repeat patients/readmissions is uncontrolled relapse. One indicator of the quality and performance of the RSJD is to reduce the readmission rate, in 2015 the RSJD reduced the readmission rate to only 0.37%. [1].
The hospital implements quality management strategies such as total quality management, quality assurance, and continuous quality management. This strategy tends to focus on management aspects. The following professional aspects will review the definition. Clinical pathway (CP) is an integrated service planning concept that summarizes every step given to patients according to medical service standards, nursing care and other evidence-based services with measurable results. Several researchers have proven the implementation of clinical pathways. Implementation of clinical pathways in opiate therapy patients with methadone, can reduce the cost of therapy and the complications that arise are well controlled. concluded that the implementation of clinical pathways in the therapy of alcoholics, although not related to the length of stay (LOS) but was strongly related to outcome.
Devapriam et al., [2]: implementation of clinical pathways can increase the capacity of per-unit services, shorten the length of stay (LOS), increase the frequency of unit visits, timely assessment of care, and reduce variability in quality. concluded that the implementation of clinical pathways can calculate all types of guarantees or financing for each episode of treatment. Barbieri found significant results in the implementation of clinical pathways for care with a structured organizational approach (clinical governance) from the aspect of quality and low-cost service processes. Cheah said that the implementation of clinical pathways significantly reduces the treatment period and without any side effects or good outcomes. Susi Research, 2009; Chan and Wong, 1999; proves that clinical pathways are associated with increasing cost-effectiveness and significantly reducing the length of treatment.
Several other researchers have found evidence that treatment in one form of regulation (similar to a clinical pathway) can prevent relapse. Prince [3] and Marchisio,proved that making a scheduled treatment similar to a clinical pathway can be used as an indicator of reducing the three-month relapse rate. Before the intervention, the mean of relapse in the intervention group was 30.38% and the control group was 27.54%. After the intervention, there was a 20% reduction in relapse. In the schizophrenic group, 24% had an intervention, while 64% had no intervention [4-10].
Enforcement of clinical pathways for drug dependence Clinical pathways on drug dependence have not been widely studied so that research needs to be done. The implementation of clinical pathways that have been applied, can affect the outcome [11-15]. This study aims to analyze the effect of clinical pathway implementation on service outcomes in the drug rehabilitation program at RSJD Atma Husada Mahakam. The results of the study can be used as an evaluation of the clinical pathway implementation process for the inpatient drug rehabilitation program at RSJD Atma Husada Mahakam. The focus of the research relates to what is in the following picture (Figure 1).
Method
This research method uses a survey model with a quantitative approach that focuses on 111 respondents (patients) who follow an inpatient drug rehabilitation program at Atma Husada Hospital (RSJAH) Mahakam, East Kalimantan, Indonesia [16-18]. The type of data is cross-sectional with analytical observation and literature review. Primary data was obtained from data from clinical pathway forms taken from addicts' medical records and reports on costs for services in drug rehabilitation programs [19-25]. The data analysis technique used the reliability and validity test of the instrument through the SPSS version 22 program, with the data analysis technique in the form of multiple linear regression and associative-causal. This is intended to be able to determine the relationship of influence between the independent variable and the dependent variable through partial and simultaneous tests and prove whether the alternative hypothesis (Ha) is accepted or rejected [25-30].
Research Result
Descriptive Analysis
Based on the results of the study, it was obtained that the description of the status of new patients was still greater than that of old or repeat patients. In (Table 1) in 2015 new patients were 84 addicts (75.7%) and in 2016 new patients were 102 addicts (89.5%). According to the 2016 BNN survey, the prevalence of drug abuse in East Kalimantan is 3.1% of the population aged 15 - 49 years. 10% of abusers experiencing health problems need to get medical help BNN, The prevalence rate of ever used decreased from 8.1% in 2006 to 3.8% in 2016. With the 2012 Accreditation plenary category, the Atma Husada Hospital has an impact on the stigma of mental illness and narcotics [31-35].
Gender of respondents 84.8% are male. The results of this study according to the theory that there are more addicts in men than women, men are more at risk of using drugs than women. The ratio of men to women is about 4 to 1, meaning that among 4 male users there is 1 woman who has tried [36]. The prevalence rate was 13.7% for men and 3.3% for women (2006), while in 2016 it was 6.4% for men and 1.6% for women. The prevalence rate of ever tried using men tends to decrease from 13.7% (2006) to 6.4% (2016). However, in the female group, the trend of decreasing prevalence rates forever and a year using drugs began to be seen from 2009 to 2016 (BNN Survey, 2016).
According to data from the US Substance Abuse and Mental Health Services Administration in 2013, men are more dominant than women in substance abuse of all types and men often overdose and die than women. Including abuse of doctor's prescription. For most age groups, men have a higher level of dependence. However, women can also experience dependence. If women are dependent, the risk is stronger. Robbins et al 1999; Hitschfeld et al 2015; Fox et al 2014; Kennedy et al 2013 and more severe relapses, including women experiencing many legal and social complications including asocial behaviour and abuse. sexual. This problem causes the prevalence of women to be smaller than men [37-45].
Meanwhile, based on age group, table 4.3 was found in 2016 the most age groups were 17-25 late teens group of 115 patients (51.1%) and 26-35 years of early adulthood, 68 patients (30.2%). In 2015, the age group of 17-25 late teens was 58 patients (52.3%). In 2016 at the age of 17-25 late teens as many as 57 patients (50.0%), looking at this number it can be concluded that drug dependence users are dominated by the age group of late teens and early adults. Meanwhile, the education level of most drug rehabilitation patients is junior high school and senior high school, namely 175 (77.7%). In 2015, 2016 consecutively were 80 patients (72.0%), 95 patients (83.3%). However, the large proportion of drug abusers with a bachelor's degree in education does not mean they graduated, some of them are no longer in the campus environment, but are already working in various sectors or even some of them may be unemployed [46-50].
Meanwhile, judging from marital and unmarried status, the most addicted respondents were unmarried status with 121 (53.8%); 56.1% in 2016 and 51.3% in 2015. The place where addicts live is still the most in Samarinda City in 2015 there were 87 patients (78.4%) and in 2016 there were 48 patients (42.1%). In 2016 after the mandatory reporting program (IPWL) and the rehabilitation program for 100,000 addicts, the city of Balikpapan had 19 addicts, as can be seen in Table 1 below
Inferential Descriptive Analysis
LOS Drug Rehabilitation Patient
The average value for the length of stay for drug patients in 2015 or before the implementation of the clinical pathway, which was 42.29 days and in 2016 or after the implementation of the clinical pathway, which was 43.41 days, wherein 2015 it was 74 (66.7%). Meanwhile, in 2016 there were 65 (57.0) less or equal to the average value. The results of the independent sample t-test for LOS obtained p-value = 0.022 < 0.05, which means that there is a significant effect between LOS in 2015 (before clinical pathway implementation) and 2016 (before clinical pathway implementation).
Rehabilitation Patient Fee
The average cost in 2015 was Rp. 14,550,357.87 and in 2016 of Rp. 14,525,219.48, where the number of paying patients is below the mean value of 138 (61.3%). Regulation of the Minister of Health of the Republic of Indonesia. number 50 of 2016 that the cost of drug rehabilitation for a 1-month package is Rp. 6,500,000,000.00. When compared, the Ministry of Health tariff is much lower, if converted to days the Ministry of Health tariff is Rp. 216,666,-/day. the results of the independent sample t-test for the cost of care obtained a value of p = 0.98 > 0.05, which means that there is no significant effect between the cost of care in 2015 (before the implementation of the clinical pathway) and 2016 (before the implementation of the clinical pathway).
Service Quality
There are still a lot of new patient data from old or repeat patients. In 2015 new patients were 84 addicts (75.7%) and in 2016 new patients were 102 addicts (89.5%). From the repeat visit data in 2015 data, addicts who were readmission 2 times were 27 addicts (34.3%) while in 2016; addicts who were treated >2 times there were 12 addicts (10.9%). The results of the independent sample t-test for readmission obtained p-value = 0.006 < 0.05, which means that there is a significant effect between readmission in 2015 (before the implementation of clinical pathways) and 2016 (before the implementation of clinical pathways). Based on the results of the independent sample t-test of the clinical quality variable, the p-value = 0.042, the exit method p = 009 and the visit status p = 006 of the three variables, the p-value = < 0.05, which means a significant influence between clinical quality in 2015 (before implementation of clinical pathways) and 2016 (before the implementation of clinical pathways) [51-57].
Consumer Satisfaction
The satisfaction index of addicts who are being treated in the rehabilitation room is an average of 78.0%. All respondents' satisfaction variables gave satisfying answers above 93.3% to the implementation of clinical pathways asked respondents. The inferential statistics of the findings can be tabulated as follows (Table 2):
Discussion
With law no. 35 of 2009 on Narcotics article 54 that addicts must be rehabilitated medical and social rehabilitation, with PP no. 25 of 2011 concerning mandatory reporting for drug addicts, following the mandate of the narcotics law that mandatory reporting is the rehabilitation process for addicts at a mandatory reporting institution appointed by the ministry of health and social affairs. Although the diagnosis of drug dependence is included in ICD IX, it is not included in the BPJS health financing, so the government through this mandatory reporting program uses separate financing through the IPWL program. The regulation of the Minister of Health has been revised 3 times (Permenkes No. 50 of 2015) regarding the mandatory reporting technical guidelines for addicts and the procedures for financing and billing inpatient and outpatient rehabilitation costs for addicts.
The purpose of the clinical pathway is an efficient and effective rehabilitation process, reducing variations in procedures and reducing costs. Although cost savings are important, the use of clinical pathways must be evaluated, because the main focus is quality and patient safety. Van Herck et al., 82.5% of the studies reported a positive impact on cost reduction, while 13.5% did not explain the effect and 4% a negative effect.. A 2013 study on the introduction of clinical pathways in postoperative clinical care after major head and neck surgery found a 27% reduction in per-patient costs and several other studies have identified a reduction in length of stay after. Several researchers have proven the implementation of clinical pathways. Ronny Rivani (2014); Implementation of clinical pathways in opiate therapy patients with methadone, can reduce the cost of therapy and the complications that arise are well controlled.
Lacko et. al (2008): concluded that the implementation of clinical pathways can calculate all types of guarantees or financing for each episode of treatment. Barbieri (2009): found significant results in the implementation of clinical pathways for care with a structured organizational approach (clinical governance) from the aspect of quality and low-cost service processes. Cheah (2005): said that the implementation of clinical pathways significantly reduces the treatment period and without any side effects or good outcomes.
The use of clinical pathways has been associated with reduced hospital complications (Rotter et al., 2010) and improved service quality. Van Herck et al. found that 65.5% of the studies reported a positive effect on the outcome, while 32% reported no association with outcome. (Van Herck et al., 2000). Dowdeswell and Yasbeck cited previous studies providing quality and outcome for geriatric patients with depression, (Hindle, Dowdeswell and Yasbeck, 2004). According to Nielsen and Nielsen (2015) that the implementation of clinical pathways in the therapy of alcoholics, although is not related to the length of stay (LOS) but is closely related to the outcome.
The Avalos standard is based on the Minister of Health Regulation No. 50 of 2015 that the 1 monthly package for inpatient rehabilitation treatment is a minimum of 30 days. The average value for the length of stay for drug patients at the Atma Husada Mahakam Mental Hospital in 2015 or before the implementation of the clinical pathway was 42.29 days and in 2016 or after the implementation of the clinical pathway was 43.41 days, wherein 2015 there were 74 (66.7%) while in 2015 2016 as many as 65 (57.0) less or equal to the average value.
Van Herck et al. stated that 62.2% of previous studies had a positive effect on satisfaction, only 29.7% had no effect on satisfaction. Including the research of Renholm, Bryson and Browning who agree that there is an improvement in patient satisfaction. One of the potential benefits of the care pathway is to improve communication between professionals. While one study revealed that although integrated clinical pathways resulted in better health care trust, there was little evidence to suggest that interpersonal relationships and communication needed to be improved, although there was no measurable improvement. On the other hand, based on clinical results, interprofessional communication improved. Interdisciplinary teamwork can be supported by clinical pathways in other fields (Figure 2).
Conclusion
In this study, three important things can be found, first, the clinical quality which consists of a) patients running away, b) forced discharge, and c) readmission is highly dependent on the implementation of clinical pathways, secondly, the implementation of clinical pathways has no connection at all with costs. drug rehabilitation treatment, and thirdly the application of clinical pathways makes an important contribution to the satisfaction of patients being treated for drug rehabilitation. This means that the satisfaction factor makes an important contribution to drug rehabilitation services at the Atma Husada Mahakam Hospital.
This means that the service outcomes provided by the Atma Husada Mahakam Hospital are generally good. This can be shown by the number of high satisfaction responses from respondents to each research variable. Similarly, the service quality variable from the five dimensions has a positive and significant influence on customer satisfaction. This reinforces the previous theory that the provision of quality services can certainly create satisfaction for everyone, including the treatment of drug rehabilitation patients.
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3 Things You Can Do To Prevent Hospital Readmission
Hospitalization, either planned or unplanned, is stressful for both the patient and the family. When a loved one is readmitted to the hospital due to relapse or failure of improvement, not only it increases the stress but also the financial burden. Besides, readmission increases the risk of catching an infection. Today, we have mentioned a few things that can help in preventing hospital readmission of your loved one after their discharge.
Be there when the doctor is giving post-discharge instructions
No matter whether your loved one is fully capable of understanding the doctor’s instruction or not, it is vital to have an extra set of ears. Take notes when the doctor gives the patient the post-discharge care plan. It is always good to have someone to hear all-important instruction, in case something crucial slips through their mind. After spending time in the hospital, most patients avoid or pay little attention to post-care plans in the eagerness to get back home.
Learn about prescribed medications
Hospital discharge doesn’t always mean the patient has been fully recovered. They still need to follow some care-instructions and take prescribed medications on time. When listening to the doctor’s post-discharge plan, understand what medicines are being prescribed, and when should it be given to the patient. Also, ask them about possible side effects. Set alarms or reminders whenever they need to take medicines to keep track of their medications.
Avoid post-hospital syndrome
Patients who don’t get adequate sleep sometimes suffer from the post-hospital syndrome. After spending time in a hospital, they feel disoriented when they come back home. For instance, they feel the light is bright or surrounding is unfamiliar. In such cases, it is important to make your loved ones comfortable at home. Besides, make sure they get proper nutrition and stay hydrated after discharge and encourage them to lay low for full-recovery.
These were a few things that you can follow to prevent hospital readmission of your loved one after their discharge.

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Hospital Administrator Invents Time Travel to Eliminate 30 day Readmission Penalty
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The small town community of Westbrook, NC was in shock last week as its local hospital VP of operations, Mr. ...
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Emergency Department Visits After Elective Spine Surgery
Emergency Department Visits After Elective Spine Surgery
Neurosurgery, Volume 85, Issue 2, August 2019, Pages E258–E265
Emergency department (ED) overuse is a costly and often neglected source of postdischarge resource utilization after spine surgery. Failing to investigate drivers of ED visits represents a missed opportunity to improve the value of care in spine patients.
OBJECTIVE: To identify the prevalence, drivers, and timing of ED visits…
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Emergency Department Visits After Elective Spine Surgery
Emergency Department Visits After Elective Spine Surgery
Neurosurgery, Volume 85, Issue 2, August 2019, Pages E258–E265
Emergency department (ED) overuse is a costly and often neglected source of postdischarge resource utilization after spine surgery. Failing to investigate drivers of ED visits represents a missed opportunity to improve the value of care in spine patients.
OBJECTIVE: To identify the prevalence, drivers, and timing of ED visits…
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