Space Pirate Mito is weird because it has a very clumsily handled sex change of its protagonist where it's like "Your body is female now so you have to be a girl" and nobody ever seriously challenges this. Iirc season 1 ends with the protagonist trying to "find a planet where I can be a boy," but this goal has been abandoned by season 2 with no particular explanation as to why.
...However, there is a character who challenges this attitude with regard to himself, as he has a gender identity (male) that is at odds with how he is perceived by those around him (neither male nor female) due to his physical body. and he is a villain but he is never vilified for this; if anything, it seems like it's meant to make him more sympathetic.
It's kind of interesting that there are no parallels drawn between their situations. I think the two of them having a heart to heart, whether in between seasons or post-series, would make for a very interesting fanfiction, although I don't plan to write it and I doubt anyone else will as the series is quite obscure.
