Five R-410A Replacements Go Head to Head: R-290 Takes Efficiency, R-454B Takes Emissions
Five refrigerants are competing to replace R-410A under the HFC phasedown, and a 2025 Springer study finally ran them all through the same head-to-head analysis: R-32, R-290 (propane), R-454B, R-454C, and R-513A, scored on energy, exergy, and total environmental impact.
The efficiency winner: propane. R-290 hit a COP of 7.91 at the study's optimal operating point against 7.49 for R-410A, a 5.6% edge, plus the best exergy efficiency of the group at 0.52. R-454C brought up the rear at 5.80.
But the emissions scoreboard flipped the podium. On Total Equivalent Warming Impact, which counts refrigerant leakage AND the emissions from the electricity a system burns, R-454B came out cleanest at 13.3 metric tons CO2e, about 16% below R-410A. R-290 landed at 14.8.
The twist: R-454C finished dead last at 18.4 tons despite carrying the lowest GWP of any blend in the test. Poor efficiency means more power-plant emissions year after year, and that swamps the low number printed on the cylinder. TEWI counts the meter.
The practical read: the OEMs bet well. Carrier and Trane went R-454B, which takes the emissions crown. Daikin and Goodman went R-32, which ran about even with R-410A while cutting GWP by roughly two thirds. And propane's efficiency win keeps its A3 asterisk; charge limits keep it out of US ducted splits, so you'll meet it in window units and European monoblocs instead. R-513A, the lone A1 nonflammable in the lineup, ran mid-pack on every measure, which is about the trade you'd expect for skipping flammability entirely.
None of this changes which cylinder lands on a service truck. The manufacturers decide that. It does change how you explain the transition to a customer staring at a changeout quote, because two of the five candidates beat the outgoing refrigerant on the metrics that matter.
The study: Ashour et al., International Journal of Air-Conditioning and Refrigeration, 2025.
What it means for the cylinders on your truck: ServiceMag












