Pollution of water bodies with pharmaceutical organic recalcitrant has been a threat to living thing and its environment due to unknown impart and possible damages. This, however necessitate the present study which was focused primarily on the development of model, optimization and kinetic reactivity on the application of Photo-Fenton process on degradation of a barbiturate (5-ethyl-5-phenylhexahydroprymidine-4,6-dione) in aqueous solution. The principle of this method is based on the in-situ generation of hydroxyl radicals from H2O2 and reconversion of Fe3+ to Fe2+.Influences of major operating parameters on the removal efficiency were investigated using Central Composite Design (CCD) of Response Surface Methodology (RSM). 22µl H2O2 and 8.8mg Fe2+ at pH 3 was found to be the optimum with 97.02% removal within 30minutes reaction time. From the kinetic study, it was observed that as the initial dose decreases to 100mg/L, 99.77% removal was achieved and at 50 & 75mg/L, 100% achieved within 10minutes. Both statistical and experimental validations of the Model were verified and found to be in good agreement. Pseudo-first order kinetics reaction rate and half-life were obtained at 0.096min-1 and 7.22mins respectively at a regression (R2) of 0.913. Electrical energy per order (EE/O) and cost (Naira) of electrical energy at optimum conditions for this experiment was found to be 1.96kWh/m3 and 50.41₦/m3 respectively.