#proanthocyanidin

These specials are available in South Africa & arrangements can be made to meet in Sedgefield, Western Cape for collection. For other areas of South Africa, a courier charge will be added.

http://www.health24.com/Diet-and-nutrition/Vitamins-minerals-and-supplements/Free-radicals-and-chronic-disease-20120721#.UYbgBMLkQ4U.tumblr

This is a comprehensive yet easy-to-understand article that explains what free radicals are, how we are exposed to them and how to combat them and the chronic diseases associated with them. (click on the title to go to article)

The last paragraph, first sentence of the article states "And supplement your diet with antioxidants, such as the proanthocyanidin complex found in grape seed extract to boost your natural antioxidant system."  Proanthocyanidin is the FIRST ingredient in Isonotix OPC-3!

Now a 90-Day supply is ONLY $69.95 PLUS $1.40 CashBack!  That's 76¢ a Day!

(NaturalNews) Used throughout Europe to prevent and treat a variety of health conditions, grape seed extract is a powerful antioxidant that can be used to benefit the body in many ways. Grape seed has antioxidant, antiallergenic, antihistamine, anti-inflammatory and immune boosting properties and it can be instrumental in helping the body fight viruses, allergens, and carcinogens. Because of its antioxidant properties, grape seed extract is considered an anti-aging wonder. Antioxidants are the most important nutrients for the skin. The bioflavonoids in grape seed extract help strengthen and protect cell membranes from oxidative damage caused by free radicals. Its antioxidant properties are considered to be stronger than those of vitamin C and Vitamin E. It helps to repair connective tissue while promoting skin enzyme activity. Grape seed extract aids wound healing by helping to regenerate damaged blood vessels and clearing harmful bacteria from the wound. Wrinkles and sagging skin, a common age old concern, particularly in women, is caused by harmful free radical activity. Aging is caused by years of physical wear and tear on the body and it can be hastened by poor lifestyle choices, such as a poor diet, smoking and the use of drugs and alcohol. Changing to a healthy lifestyle, including proper diet and supplementation, can ward off and even reverse aging. Grape seed extract contains one of the richest sources of oligomeric proanthocyanidins (OPC's), which makes it one of the most powerful antioxidants available. The use of grape seed extract, together with implementing a healthy lifestyle, can make it possible to reverse much of the damage that has caused lines and wrinkles in the skin. The body can benefit in many other ways from using grape seed extract. It can be used to prevent health problems which include cardiovascular disease, varicose veins, edema, and arthritis. Grape seed extract also acts as a natural anti-histamine, moderating allergic responses by reducing histamine production and boosting the immune system. Another important area that grape seed extract can help is eye health. Grape seed extract is frequently recommended to combat macular degeneration, cataracts, and eye strain. Studies have shown that 300 mg daily reduces eye strain from prolonged computer use in 60 days. Grape seed extract can also be effective in treating conditions such as ADD, as it aids in regulating the neurotransmitters in the brain and inhibits the breakdown of norepinephrine and dopamine. Grape seed extract is one of the few antioxidants that can help to protect nerve and brain tissue by penetrating the blood brain barrier. Some additional benefits which it provides are: *Prevents formation of plaque in arteries. *Improves mental alertness and may help to prevent senility. *Prevents tooth decay * Helps to prevent osteoporosis *May interfere with cancer cell growth and proliferation *May inhibit virus expression and replication in individuals with HIV *Aids in poor circulation *Addresses complications due to diabetes *Relieves constipation *It is water and oil soluble, delivering antioxidant protection by penetrating cell membranes throughout the body. These are just some of the benefits that one can derive from grape seed extract, a powerful supplement that should not be overlooked.

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Dr Rouanet and his co-workers divided hamsters into three groups: One group received a standard diet, one group was fed a high-fat diet, and the third received the high-fat diet and the grape seed extract (provided by Partoeno, Bordeaux).

After 12 weeks on the diets, the researchers found that animals on the high-fat diet only had increased abdominal fat, compared to the hamsters on the standard diet.

On the other hand, the hamsters in the grape seed extract group did not have increased abdominal fat, they said.

  Grape seed extract is made by taking the seeds out of the grape and simply pressing them.

Most grape seed extract pills I've seen are standardized to about 50-100 mg of proanthocyanidins.

So how does this compare to grapes... As wikipedia says...

In red wines, total oligomeric proanthocyanidin content, including catechins, was substantially higher (177.18  ± 96.06 mg/L)

So if there are 4 glasses of wine per bottle, that's about 40-45 mg of proanthocyanidins per glass - about the same as a pill of grape seed extract or half a pill.

How many grapes are in a bottle of wine? About 2.75 lbs. So clearly it would take a lot of grapes to get the grape seed extract in one pill. 

More estimates :

Grapes and grape juice were shown to contribute nearly 18% of the total ~ 58 milligrams proanthocyanidin/person/day (> 2 years old). In fact, purple grape juice had the highest average content of proanthocyanidins per serving of all beverages tested (including red table wine and fruit juices), at 124 milligrams per 8 fluid ounces.

Then I found this nugget

Apples contain on average per serving about eight times the amount of proanthocyanidin found in wine, with some of the highest amounts found in the Red Delicious and Granny Smith varieties.[7]"