The nutritional effects of Lactobacillus acidophilus (L) and Saccharomyces cerevisiae (S) on the major carps were evaluated by comparative analysis. Material and Methods. The study was carried out in three replicates in each of the control and treatment groups, trial lasted 90 days in total. Phase-I was done on C. carpio (G1) and L. rohita (G2) for one month using S. cerevisiae and L. acidophilus. G1 includes LA1, LA2 and LA3 treatments and control (C) group in triplicates while G2 have SC1, SC2 and SC3 treatments to investigate the influence of different levels (0.15%, 0.30% and 0.60%) of probiotics. Phase II, was extended for 60 days on Labio rohita with dosages @ (0.15%, 0.30%, 0.45%, 0.60%, 0.75%, 1.0 % of S. cerevisiae administered with basal fish feed to examine growth, hematology, digestive enzyme activity, stress tolerance and survival rate. Better growth performance indicated that the addition of L. acidophilus and S. cerevisae with basal fish feed was overall significant but supplementation of S. cerevisae proved itself to be more effective for the substantial rise in the growth performance (P
