Jan 12, 2021
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Cell carpet
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Angry Bird Mesothelium
A *very* reactive mesothelial cell.
i♡histo
Mesothelial cells are the cells that line our body cavities. They form the visceral and parietal membranes that line the pericardial cavity around our heart, peritoneal cavity in our abdomen and pleural cavities around our lungs. They are serous cells that secrete a fluid that helps lubricate the membranes to reduce friction when adjacent surfaces come into contact during movement (which happens every time your heart beats, you breath in and out, and when your intestines undergo peristalsis).
Presence of these cells in fluid extracted from a cavity may indicate trauma, a tumor or an inflammatory response due to bacterial, viral or fungal infection within the cavity.
Histology is from the microscope of @ali.rahbri.md [Insta]
What is Mesothelium ?
The mesothelium is a membrane composed of simple squamous epithelium that forms the lining of several body cavities: the pleura (thoracic cavity), peritoneum (abdominal cavity including the mesentery), mediastinum and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). Mesothelium that covers the internal organs is called visceral mesothelium, while the layer that covers the body walls is called the parietal mesothelium. Mesothelium is the epithelial component of serosa.
Function
The mesothelium is composed of an extensive monolayer of specialized cells (mesothelial cells) that line the body's serous cavities and internal organs. The main purpose of these cells is to produce a lubricating fluid that is released between layers, providing a slippery, non-adhesive, and protective surface to facilitate intracoelomic movement.
The mesothelium is also implicated in the transport and movement of fluid and particulate matter across the serosal cavities, leukocyte migration in response to inflammatory mediators, synthesis of pro-inflammatory cytokines, growth factors, and extracellular matrix proteins to aid in serosal repair, and the release of factors to promote the disposition and clearance of fibrin (such as plasminogen). Mesothelial cells are capable of phagocytosis and are antigen presenting cells. Furthermore, the secretion of glycosaminoglycans and lubricants may protect the body against infection and tumor dissemination.
Role in disease
Mesothelioma: (cancer of the mesothelium) is a disease in which cells of the mesothelium become abnormal and divide without control or order. They can invade and damage nearby tissues and organs. Cancer cells can also metastasize (spread) from their original site to other parts of the body. Most cases of mesothelioma begin in the pleura or peritoneum. More than 90% of mesothelioma cases are linked to asbestos exposure.
Mesothelial hyperplasia
Intra-abdominal adhesions: Normally, the mesothelium secretes plasminogen, which removes fibrin deposits. During surgical procedures, the mesothelium may be damaged. Its fibrinolytic capacity becomes insufficient and fibrin accumulates, causing fibrous adhesions between opposing surfaces. These adhesions cause intestinal obstruction and female infertility if it occurs in the abdomen, and may impair cardiac and lung function in the thorax.
Ultrafiltration failure: The peritoneal mesothelium is implicated in the long-term development of ultrafiltration failure in peritoneal dialysis patients. The presence of supra-physiological glucose concentrations, acidity, and glucose degradation products in peritoneal dialysis fluids contribute to the fibrosis of the peritoneal mesothelium, either by epithelial-mesenchymal transition or increased proliferation of existing fibroblasts. A fibrosed peritoneum results in the increased passage of solutes across the peritoneum and ultrafiltration failure.
Mesothelioma and Asbestos
Mesothelioma and Asbestos - What is Mesothelioma and how is it caused by asbestos? There are literally thousands of pages of data and general information amassed on the subject of Mesothelioma. However, upon hearing people struggle to pronounce the word, that the need for understanding becomes apparent. The issues surrounding this life altering cancer are massive. The wake of changes which trails through the lives of citizens, our court system, the insurance industry and the medical community is wide and far reaching. These things continue to affect society on every level. Unfortunately, Mesothelioma and asbestos are becoming synonymous terms in the medical and legal fields. Mesothelioma is considered to be a rare cancer Mesothelioma is considered to be a rare cancer in which malignant cells appear in the mesothelium. The mesothelium is the protective sac covering most of the internal organs of the body. Most people who develop the cancer have done so by working on jobs where they inhaled particles of asbestos. The malignant cells may invade nearby tissues and organs. Cells could spread from the original source to other places in the body. Despite the increase in reported cases in the last couple of decades, the disease is still relatively rare. There are around two-thousand new cases diagnosed annually in the U.S. Ads from many law firms Ads from many law firms state that millions of dollars are available to anyone who has been diagnosed with Mesothelioma. Issues like blame and accountability are brandished at private businesses and insurance agencies alike. It is interesting to read the disclaimers at the bottom of these ads. Many of them state that previous law suit victories may not necessarily be the result in similar circumstances. Language such as this is indicative to the confusion attached to the issues surrounding Mesothelioma. Reliable and accurate information is paramount to our understanding this very difficult disease. Choosing a Mesothelioma Lawsuit Lawyer Mesothelioma is one of the occupational diseases. The main factor that causes this disease is exposure to asbestos. Symptoms of this disease start showing up around twenty to thirty years after their exposure to the mineral and therefore, it is common amongst the senior citizens who have worked in an environment where asbestos was utilized. Filing a lawsuit, no doubt, is a tiring and long process. But it is essential to file the lawsuit as soon as the disease is diagnosed, so that you are able to receive compensation. It is this compensation that will help you in financial terms by taking care of the various medical expenses. It is recommended to hire an experienced mesothelioma lawsuit lawyer for filing a suit. A professional and experienced lawyer can help in speedy processing of the suit as well as claims. Below listed are a few questions, that will help in making a good and fair decision regarding the selection of trusted mesothelioma lawyers as well as firms. 1. For how long the firm has been handling these types of cases? 2. Currently, how many such cases they are handling? 3. Number of cases terminated successfully by them in the recent past. 4. Will the law firm initiate on your case will refer it to some other law firm? If they will refer to some other firm, it is essential to research about the credentials of the referred firm. 5. Are the lawyers in the firm, handling appellate and various other related legal issues well versed and qualified? 6. How many appealed cases have been handled successfully by the law firm? What is their track record? Searching for a reliable and experienced lawsuit lawyer is no more a tedious job. With the advent of internet technology, you can easily browse from one website to other and search for a lawyer, his details, his experience and other relevant information. Mesothelioma Settlements - What You Need to Know Mesothelioma and Asbestos - If you have plans to file for mesothelioma settlements, it is important for you to be knowledgeable about your current situation. Although you can always seek the assistance of asbestos law firms for the smooth processing of your claims, it would be good to know firsthand the essential details about mesothelioma settlements as well. 1. Mesothelioma lawsuits can be very expensive. The amount for mesothelioma settlements usually run into millions of dollars. This is because with mesothelioma, it is the life of the victim that is always at risked. Treatment through radiation therapy and chemotherapy, and management of the illness are very costly and most often than not, in a year or two after diagnosis, the patient almost always dies. 2. Mesothelioma settlements must be filed as soon as a person is diagnosed with mesothelioma and not the other way around. There are laws in every state protecting companies too. Asbestos law firms would even tell you that your illness must be backed up with medical documentation and proof of having been exposed to asbestos in the past for the smooth processing of the settlement. 3. Through the help of asbestos law firms, you can file your mesothelioma settlements in two ways: through a lawsuit or through out of court settlements. Huge multi-national companies who have huge funding value their business a lot and would rather do an out of court settlement to protect their image and best interests. But for smaller companies, they usually opt for lawsuits to give them a chance to win the case and not pay the victims any compensation. Know which of the two you're up against so you can prepare yourself for the legal battle ahead. Filing your settlement is a very challenging endeavor. While you and your family are coping with the health, physical, emotional and financial turmoil, you would also need to bear the complexity of this case. It will be in your best interest to get any of the reputable asbestos law firms in your area, hire their most skilled and experienced lawyer, collate all the proof and documents you will need, and proceed with the filing of mesothelioma settlements. By getting the best lawyer for the job, you will duly be compensated for your suffering. Don't lose hope. Filing for mesothelioma settlements may seem to take forever, but with the success rate of these kinds of cases, and with the best of the asbestos law firms supporting you, you will surely see the light at the end of the tunnel, and begin your healing process.
Mesothelioma and its Link to Asbestos
What is Asbestos? Asbestos is the common name of a string of highly strong and fibrous minerals with detachable, long and thin fibers. Asbestos fibers are so strong and flexible such that they can be spun and woven and when they enter into the lungs, they will stay there for long periods of...
http://www.ebestproducts.com/2014/06/mesothelioma-link-asbestos/
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How do Asbestos Particles Get into the Lungs & Air Passages?
When humans inhale, there are more things that enter the lungs than just air. Mist, fumes and dust particles that are suspended into the air also make their way into the lungs. How far these dust particles travel down the respiratory system depends on the particles’ size, shape, density...
http://www.ebestproducts.com/2014/05/asbestos-particles-lungs-air-passages/