May 6, 2021
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Lens Cleaner
Anyone who uses contact lenses knows that you need to clean them each night with a sterilising solution. This stops any unwanted micro-menaces infecting your eyes via the lenses, but there are some threats that can survive even this treatment. Acanthamoeba castellanii is an amoeba species that can cause keratitis and blindness, and is a growing threat in some countries. To develop treatments or preventions, researchers need to know more about its structure, so tracked three key proteins and their places in the developing amoeba cell walls. By variably staining the different proteins at different periods of growth (pictured at the second, third, and mature stage), they could pinpoint each protein’s position in the inner and outer wall, and conjoining structures. The wall is a key factor in the bugs’ resistance to both lens solution and antibiotics, so understanding how its built might help develop treatments to exploit any weaknesses.
Written by Anthony Lewis
Image adapted from work by Pamela Magistrado-Coxen and colleagues
Department of Molecular and Cell Biology, Boston University Goldman School of Dental Medicine, Boston, MA, USA
Image originally published under a Creative Commons Licence (BY 4.0)
Published in PLOS Neglected Tropical Diseases, May 2019
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Corneal Ulcer (Keratitis) :
An open sore on the cornea is known as a corneal ulcer (also known as keratitis). In the same way as a watch crystal covers the face of a watch, the cornea covers the iris and the circular pupil. A corneal ulcer is most commonly caused by an eye infection, although it can also be caused by severe dry eye or other eye diseases.
Here’s a picture of my eye after my cornea transplant, courtesy of Acanthamoeba keratitis. Pretty rad actually.
Keratitis is an inflammation of cornea.