#il8

igor larionov talking about alexander mogilny right after he defected (translation under the cut)

Inflammatory cytokines are signaling proteins released by immune cells that regulate inflammation and immune responses. They play a key role in defending against infections, but excessive or chronic inflammation can contribute to autoimmune diseases and other health issues.

• IL-17: A pro-inflammatory cytokine primarily produced by Th17 cells, IL-17 promotes the recruitment of neutrophils and enhances tissue inflammation. It is involved in autoimmune diseases like rheumatoid arthritis and psoriasis.

• IL-6: A multifunctional cytokine that plays a role in both inflammation and immune regulation. It promotes the production of acute-phase proteins, stimulates B and T cell differentiation, and contributes to chronic inflammatory conditions.

• IL-8: A chemokine that primarily attracts neutrophils to sites of infection or injury. It is involved in acute inflammation and plays a role in diseases such as chronic obstructive pulmonary disease (COPD) and cancer.

These cytokines are crucial in both protective immune responses and inflammatory diseases. Since these cytokines are involved in autoimmune activity, chronic inflammation, and immune system signaling, elevated levels could suggest:

1. Persistent Inflammation or Autoimmune Activity – IL-17 is linked to autoimmune diseases, while IL-6 and IL-8 are general markers of inflammation.

2. Steroid Resistance or Incomplete Suppression – Despite being on 20 mg of Prednisone for three months, inflammation remains active, which could indicate a condition not fully controlled by steroids.

3. Chronic Immune Activation – The combination of elevated VEGF, D-dimer, and hsCRP (other previously tested & elevated immune markers) suggests possible vascular inflammation, which ties into IL-8’s role in blood vessel regulation.

What It Doesn’t Necessarily Mean

• Not Proof of Infection – While these cytokines can rise during infections, additional markers (like white blood cell count, which for the record for me is ALWAYS elevated) would be needed to confirm.

• Not Diagnostic of a Specific Disease – Many conditions, including autoimmune diseases, chronic infections, and metabolic inflammation, could cause these elevations.

Conclusion: We never have a fucking clue about anything at all pretty much. If you have any ideas, please holler.

Feiyue's Bovine IL-8(Interleukin 8)  ELISA Kit is an ELISA reagent for detection of IL-8, plasma or cell with sensitivity, specificity and consistency.

Interleukin 8 (IL-8 or chemokine (CXC motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the CXCL8 gene. IL-8 is initially produced as a precursor peptide of 99 amino acids which then undergoes cleavage to create several active IL-8 isoforms. In culture, a 72 amino acid peptide is the major form secreted by macrophages.

This kit uses sandwich ELISA to detect the concentration of Bovine IL-8.