Healing Childhood Traumatic Brain Injury at any time
Adi Shabi Shlifer, Gil Suzin, Ran Shorer, Erez Lang, Shachar Finci, Karin Elman-Shina, Keren Doenyas-Barak, Shai Efrati. Hyperbaric oxygen therapy improves post-concussion symptoms in adults with childhood traumatic brain injury: a retrospective cohort study. https://pmc.ncbi.nlm.nih.gov/articles/PMC12440767/
SUMMARY:
Post-concussion syndrome (PCS) following childhood traumatic brain injury (TBI) can result in persistent cognitive impairments that extend into adulthood, yet it remains significantly underdiagnosed and undertreated. This study evaluated the effects of hyperbaric oxygen therapy (HBOT) on chronic neurocognitive symptoms in adults with PCS stemming from pediatric TBI.
Between 2017 and 2024, the Sagol Center for Hyperbaric Medicine and Research studied TBI before age 17, HBOT initiation after age 20, and the availability of computerized cognitive assessments before and after treatment.
Twenty-six adults (mean age 31.7 ± 8.6 years) who sustained TBI in childhood (mean age at injury 7.7 ± 5.8 years) met inclusion criteria. Following HBOT, statistically significant improvements were observed in all cognitive domains.
These improvements were independent of time since injury (mean 23.6 ± 9.3 years) and initial TBI severity. Notably, individuals with a history of mild TBI exhibited similar impairments and treatment response to those with more severe injuries. These findings suggest that HBOT may induce meaningful neurocognitive improvement even decades after pediatric TBI, supporting its potential role in long-term rehabilitation strategies for this underserved population.
SIGNIFICANCE:
Despite increasing awareness, Post Concussive Syndrome (PCS) in children continues to be overlooked by clinicians and educators. Many children experiencing long-term post-injury symptoms, whether from falls, athletic injuries, assaults, or sickness do not receive a formal diagnosis or appropriate interventions, allowing their difficulties to persist untreated into adulthood.
Traumatic brain injury (TBI), a leading cause of emergency department visits in children, has an estimated annual incidence of 150 to 400 cases per 100,000 in the pediatric population. Although most pediatric TBIs are classified as mild (mTBI), a substantial proportion of affected children—estimated between 10 and 30%—develop persistent post-concussion syndrome (PCS), characterized by long-term cognitive, emotional, somatic and behavioral symptoms. These symptoms may persist for years and interfere with academic and social functioning.
Hyperbaric Oxygen Therapy (HBOT) has recently gained attention as a potential treatment for chronic PCS. By increasing oxygen delivery under elevated pressure, dedicated protocols of HBOT may induce neuroplasticity and recovery of dysfunctional brain regions even at the late chronic phase. Clinical studies have demonstrated improvements in cognitive and behavioral outcomes following HBOT in both pediatric and adult populations with PCS.
The present study addressed longstanding PCS following pediatric TBI, and intervention with HBOT. Positive results were found even decades after the brain wound in six categories: Global Cognitive Function; Memory Function; Executive Function; Attention; Information Processing Speed; and Motor Skills.
This study provides initial evidence that HBOT can elicit significant cognitive improvements in adults with chronic PCS from childhood TBI. This evidence substantiates data already showing significant improvement in adults with TBI, irrespective of their age or the origin of the brain wound.
Given that treatment effects were not dependent on time since injury or injury severity, HBOT may represent a valuable therapeutic option even for those with longstanding symptoms. Future prospective, controlled trials are warranted to confirm these findings, elucidate optimal dosing protocols, and explore adjunctive interventions and assess the long-term durability of treatment effects through extended follow-up.
These results also highlight the need for early recognition, long-term follow-up, and access to rehabilitation for pediatric TBI survivors, especially those with mild injuries who are often misclassified and undertreated.
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The TreatNOW Mission is ending service member suicides. Along the way, we have learned that we can end suicidal ideation, help end symptoms of PTSD, get patients off most of their drugs, and heal brain wounds to end the effects of Concussion, BLAST injury, mild TBI, Persistent Post Concussive Syndrome, and polytrauma from Operator Syndrome, AHI, and Burn Pits. No Veteran or civilian has ever been killed or hurt while undergoing HBOT treatment for TBI/PTSD.
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