#haloperidol

I'm liking these quizzes so let's see if we can crowdsource some more blorbo-saving fun.

Keep in mind, I'm looking for the most correct answer as medical and/or nursing science knows it, not the whumpiest one.

All the answers can be found somewhere on my blog.

Common Brand Names: Haldol

Therapeutic Class: A butyrophenone-derivative antipsychotic agent

Common Injectable Dosage Forms:

Injection: 5 mg/mL in ampules, vials, and syringes

Decanoate Injection: 50 mg/mL and 100 mg/mL

Dosage Ranges:

For prompt relief of symptoms in the acutely agitated patient, the initial dose is recommended as 2-5 mg and may be repeated as often as every hour, although dosing every 4-8 hours may be sufficient in some patients. Dosage and frequency should be titrated based on patient’s tolerance and response. The dosage of decanoate salt is roughly 10-15 times the previous effective daily dose, but not to exceed 100 mg total.

Administration and Stability: The drug may be given undiluted (5 mg/mL) for IM use, and may also be given by SLOW direct IV injection. The IV route should only be used as a last resort. The DECANOATE salt must NEVER be given by IV route. Haloperidol lactate should be stored at room temperature and protected from light. Haloperidol lactate may be administered IVPB or IV infusion in D5W. NS should not be used due to stability and incompatibility issues. pH 3-3.8

Pharmacology/Pharmacokinetics: Haloperidol appears to have strong central antidopaminergic action and weak central anticholinergic action at the subcortical level of the brain, and also acts through inhibition of catecholamine receptors. The onset of sedation is within 20-60 minutes after injection and duration lasts from 2-8 hours (up to 3 weeks for decanoate form). Protein binding is approximately 90%, with an elimination half-life in the liver with excretion via the urine and feces.

Drug and Lab Interactions: May be additive with, or potentiate, the actions of other CNS depressants. May produce an acute encephalopathic syndrome when given concomitantly with lithium.

Contraindications/Precautions: Because severe hypotension may result with haloperidol use, corrective measures should be ready to initiate should this reaction occur. Caution should be exercised when used with other CNS depressants (including alcohol) to avoid oversedation. Contraindicated in patients with a history of hypersensitivity to droperidol or other butyrophenones, or those with parkinsonian syndromes. Patients should be carefully and frequently monitored for tardive dyskinesia and/or extrapyramidal symptoms. Pregnancy Category C.

Monitoring Parameters: Vital signs, lipid profile, fasting blood glucose/Hgb-A1c, BMI, mental status, EPS

Adverse Effects: The most common adverse effects with haloperidol are extrapyramidal reactions, tardive dyskinesia, and other CNS reactions. Other reported effects include hypotension, tachycardia, respiratory depression, cogwheel reactions, akathisia, EEG changes, and an acutely dangerous reaction called neuroleptic malignant syndrome.

komm schrei Laut für ein letztes mal.

Wir nehmen dir das Leben

noch bevor's in der Brust aufhört zu beben.

Bist noch voll da drin, viel Lust, keine Grenzen

doch sieh, bei uns werden sie alle Stilldemenzen.

Komm in's Pflegeheim

und dein Kopf verliert noch den leichtesten Reim.

Mit Lautdemenz passt du hier nicht rein,

und wenn du nicht mehr Schluckst,

mörsern die Pfleger dir die Pillen sogar fein,