#hallmarks

This is a long shot, but my friend asked me to plumb the depths of tumblr's wisdom, so I will. She found this lovely châtelaine on a French auction site, but it's just marked 'châtelaine en argent anglais' and then a list of the accessories, no place or time given.

There is, however, the above nice picture of the marks. Does anyone happen to have the knowing of these symbols?

EDIT: Solved!

Quick and clever sleuths have determined this piece is most likely English sterling silver from London manufactured in 1893 by William Comyns & Sons.

I bought a keepsake Doctor Strange ornament from Hallmarks! I’ll be placing him next to my other Doctor Strange figures!

Main 6

Self sufficiency in growth signals 

Insensitivity to anti-growth signals 

Tissue invasion & metastasis 

Limitless potential for replication 

Sustained angiogenesis

 Evading apoptosis 

Self-sufficiency in growth signals 

Cells need constant cues in order to stay alive 

These include external signals from growth factors

These often act by allowing progression through the cell cycle 

Cancer cells gain the ability to grow and divide independently of these external signals. 

“Accelerator jammed on” 

Cell Cycle and tumour growth 

Checkpoints exist at various points to prevent abnormal cells from dividing 

growth factors can influence the progress of cells through the cycle 

Many oncogenes and TSGs are involved in cell cycle regulation 

Progress through the cycle is regulated by a number of cyclins and cdks

Insensitivity to anti-growth signals 

As well as growth cues cells receive signals which limit cell growth and division 

Also regulated by growth factors

Cancer cells Insensitivity to anti-growth signals 

No Brakes

Tissue invasion and metastasis 

90% of all cancer deaths are caused by metastasis i.e. NOT the primary tumour 

detachment from tumour mass 

motility - move through stroma/mesenchyme 

intravasation 

extravasation 

Limitless potential for replication

Normal cells show a limited capacity for replication - before reaching the Hayflick limit = senescence 

This forms part of the aging process 

Cancer cells achieve immortality by disabling pRB and p53 

The counting device for cell doublings is the telomere: which loses DNA at the tips of every chromosome during each cell cycle 

Many cancers show an upregulation of telomerase, the enzyme that maintains telomeres 

Sustained angiogenesis 

Hypoxia leads to:

activation of HIF-1 transcription factor 

HIF-1 activates target genes such as: Vascular endothelial growth factor (VEGF) 

stimulates endothelial migration 

promotes endothelial cell proliferation 

Evading apoptosis 

Apoptosis is an important part of normal tissue homeostasis 

Entire intestinal lining replaced every 3-5 days 

 In cancer, we tend to see changes that result in: 

increased rates of cell proliferation 

decreased rates of apoptosis 

decreased cellular differentiation 

Important cancer genes involved in apoptosis 

Oncogenes:

 Bcl-2 family 

comprises of both pro- and anti-apoptotic proteins 

expression often altered in cancers to prevent apoptosis 

can be regulated by cmyc 

Tumour suppressors: 

p53 “guardian of the genome” 

initiates apotosis following DNA damage 

preventing mitosis of abnormal cells 

often lost in cancers 

Autophagy 

another form of programmed cell death - literally means “eating yourself”

degradation of cellular components to allow recycling and a source of energy in a starving cell 

involves lysosomes 

god bless the made-for-tv (holiday) romcom 

(this is a selection)

Estate gala, love triangle, a 90-year-old family matriarch named Pippa

Widower gets second chance at love, military museum (this has julie benz & michael shanks in it)

Memory loss, marriage rehabilitation, Christmas miracle

Reunion of old lovers, love triangle, tasty pastry

Small-town baker, mysterious calendar, secret admirer

Bike accident, coma, German Shepherd mix

$50,000 windfall, investigation, bed-and-breakfast romance

Dancing, dancing, and more dancing for two ex-lovers (this has rl couple carlos & alexa penavega and u shoudl watch it)

Wedding planning, romance between celebrity and commoner

Secret Santa, office crush, deception

Frozen water art, teamwork leading to romance (there’s always at least 1 movie abt fricking ice carving/sculpting)

Decluttering, reorganization, a toy maker, a widower getting another shot at love

Romance for romance novelists, Vermont inn (half of the appeal of hallmark movies is p shots of forests & mountains, thanks bc)

A true story about the horrors of war and the world’s unlikeliest violin

Gifts, including... the gift of love (i think keyword man got tired)

Fill-in Santa, creative use of ride-share app 

Mall drama, mall Santa, secret identities, cast members from several '80s shows

Hometown return, career-vs.-love drama, a selfless stranger named Joy

Snowmen, love triangle 

Someone trying to earn their literal wings, love triangle, Jason Biggs as Jason Biggs (this is the brenda song angry angel movie????? jason biggs???? why???)

Runaway singer, quality time on a dairy farm

Trees, a destiny-changing letter, a woman named Holly

The planning of a Christmas festival, the passage of time

Incredible shrinking kids, curmudgeonly neighbor, cat named Tinselpaws

Traumatic breakup, hot neighbor, and, well, magical Christmas ornaments

Nod to Dickens, theatrical production in jeopardy, actress-director romance

Real estate greed, old-timey Christmas store, career-vs.-love drama, sax appeal

Regal bachelor, questions of paternity, Tara Reid

Cautious romance, math tutoring, memories of Lake Tahoe

Online journalists with no Christmas plans, plans changed because of blizzard, plans to save an inn