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Migraine Is Associated with Pain in Joint Connecting Jawbone to Skull

Migraine is known to be associated with pain in the chewing muscles and has hitherto been associated with temporomandibular disorder (TMD) regardless of the frequency of migraine attacks. The temporomandibular joint acts like a sliding hinge connecting the jawbone to the skull.

A recently published study by researchers at the Medical School of the University of São Paulo – Ribeirão Preto campus (

New Research on Fragile X Syndrome Reinforces Importance of Early Detection

Fragile X syndrome—the most common heritable cause of autism spectrum disorder—is something of a phantom. It interferes with the production of a protein critical to synapse formation during a brief period in early development when the brain is optimizing its ability to process sensory input. Then it dials way down…leaving behind permanent changes in neural circuit structure that can cause low IQ,…

Oropouche Virus Could Emerge and Cause a Public Health Problem

After the Zika epidemic, which began in 2015, and the outbreak of yellow fever early this year, Brazil runs a serious risk of being afflicted by Oropouche, another virus that is widely distributed throughout South and Central America and the Caribbean. It has adapted to urban environments and is moving ever closer to Brazil’s major cities. An arbovirus transmitted by a mosquito (like Zika and…

Insight into Brain via ‘Friend of Fragile X’ Gene

We can learn a lot about somebody from the friends they hang out with. This applies to people and also to genes and proteins. Emory scientists have been investigating a gene that we will call – spoiler alert –“Friend of fragile X.”

Fragile X syndrome is the most common inherited form of intellectual disability, studied by research teams around the world with drugdiscovery and clinical trials in…

Study reveals mechanism that leads to immunosuppression after sepsis

Patients who survive severe sepsis, which is popularly known as “blood poisoning,” typically experience a sharp fall in immunity in the years following discharge from hospital and become susceptible to cancer and infections with opportunistic pathogens.

The mechanism that causes this immune system dysfunction has now been described in the journal Nature Communicationsby scientists affiliated with…

Study Reveals Immune Mechanisms Responsible for Curing Systemic Sclerosis

Systemic sclerosis is an autoimmune disease in which the immune system malfunctions and attacks the body’s own connective tissue. The most evident symptom is loss of skin elasticity, causing hardening of the skin. The most severe forms of the disease, however, may result in kidney, lung and heart failure, leading to death.

Conventional treatment with immunosuppressive drugstypically causes…

Study Reveals Essential Role of Sympathetic Nerves in Muscle Health

Contrary to what has long been believed, the role of the sympathetic nervous system in muscle tissue goes far beyond controlling blood flow by contracting or relaxing blood vessels, according to studies conducted at the University of São Paulo (USP) in Brazil.

With support from FAPESP and the collaboration of researchersat Mannheim University and Heidelberg University in Germany, a group of…