#estazolam

Medication half life? Is the amount of time it takes for your body to reduce the drug by half. It can take hours or days, depending on the half-life. Half-lives matter for different reasons. For example, the half-lives of hypnotics can have an important impact on a person. (A) Hypnotics with ultra-long half-lives (greater than 24 hours: for example, flurazepam and quazepam) can cause drug accumulation with chronic use. This has been associated with increased risk of falls in the elderly. (B) Hypnotics with moderate half-lives (15–30 hours: estazolam, temazepam, most tricyclic antidepressants, mirtazapine, olanzapine) may not wear off until after the individual needs to awaken and may have “hangover” effects (sedation, memory problems). (C  ) Hypnotics with ultra-short half-lives (1–3 hours: triazolam, zaleplon, zolpidem, melatonin, ramelteon) can wear off before the person needs to wake up and therefor can cause sleep loss. (D) Hypnotics with half-lives that are short but not ultra-short (approximately 6 hours: zolpidem CR and perhaps low doses of trazodone or doxepin) only last the a short amount of time.

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