(Keep in mind that just because Y/N / [Reader] is a variant of the heroes that doesn't mean they act/behave or even look like their counterpart.)

Like most spiderverse fics have a Spidersona! Reader / Spider! Reader, but what if reader were a variant of a Spiderman Villain and/or Ally? Maybe a: Doc Ock! Reader, Prowler! Reader, Symbiote Host! Reader, Black Cat! Reader.Or Maybe a: Silk! Reader, Iron Suit! Reader (Maybe in a way that relates to Riri Williams more than Tony Stark)

Try copying a DC Hero/Villain-esque! Reader into that and vice versa, as in a Marvel Hero/Villain-esque! Reader in a DC fic. Like a (Black) Bumblebee! Reader or Blue Beetle! Reader, they could be related to Antman in a way, but possibly in a different team(Perfect opportunity to pair with Joaquin since Sam seems to have a mini-beef with bug heroes).

A Tamaranean! Reader in the Invincible universe(that's not Starfire coded) A (Green) Lantern! Reader teaching Captain America/Steve Rogers. A Doctor Strange! Reader(or other magic user) arguing with Doctor Fate(idk...) A Deadpool! Reader, Wolverine! Reader, Black Widow! Reader

Unique powers? What about a Reader that can manipulate gravity, shapeshifting, convert energy? ... Instead of Wanda's Powers but in a different color... Unique archetypes? A impulsive speedster faster than light? A sensitive empath that can control and sense emotions? A (mute) mime that can use imaginary/invisible powers and constructs?