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Desmosomes are one of four intercellular junctions present on the lateral side of neighboring polarized epithelial cells. Desmosomes mechanically integrate adjacent cells by coupling adhesive interactions mediated by desmosomal cadherins to the intermediate filament (keratin) cytoskeletal network.
*** Esophageal squamous epithelium.
desmosome a circular, dense body that forms the site of attachment between certain epithelial cells, especially those of stratified epithelium of the epidermis, which consist of local differentiations of the apposing cell membranes.
-Exfoliatin
A staphylococcus toxin - Cleaves the desmosomes in the stratum granulosum - Separates layers of skin. - Example: Scalded skin syndrome (occurs more often in infants)
