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Melanoma drug resistance get overcome: without GSK3 cells are B-Raft of advantage
Melanoma is a type of skin cancer in which nearly half of patients have mutations in the BRAF gene that accelerate tumor growth. Although BRAF-targeted treatments, known as BRAF inhibitors, work well initially, tumors often find ways to fight back. Adaptive metabolic reprogramming with oxidative phosphorylation, anaerobic glycolysis, and autophagy are the main mechanisms of resistance, both de…
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Dabrafenib | CAS. No.1195765-45-7
Synonyms: Dabarefenib;GSK2118436;Tafinlar;Benzenesulfonamide,N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro
Chemical Name: N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethyl ethyl) -4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide
Know more:- https://www.simsonpharma.com/product/dabrafenib
