Apr 10
SPTBN2 promotes an immunosuppressive tumor microenvironment and cross-resistance to anti-cancer therapies - Research
Immunosuppressive tumor microenvironment (TME) inactivates CD8+ cytotoxic lymphocytes (CTLs). Here, we identify SPTBN2 spectrin as a key immunosuppressive regulator induced in CTLs in response to nutritional deficit. In human pancreatic and colorectal cancers, SPTBN2 expression negatively correlated with CTL infiltration and patients’ survival. In TME of mouse pancreatic and colorectal…
#Anticancer#crossresistance#doi:10.64898/2026.03.30.715365#immunosuppressive#MEDLINE#microenvironment#National Center for Biotechnology Information#National Institutes of Health#National Library of Medicine#NCBI#NIH#NLM#PMC13060094#pmid:41959129#Preprint#promotes#PubMed Abstract#Quoc Thang Bui#Raghavendra Basavaraja#research#Serge Y Fuchs#SPTBN2#therapies#tumor
