#cd8+

Link: https://sites.google.com/view/bobthebiotechquer/immunology/cells-of-the-immune-system-pt-2

The CD4/CD8 T cell ratio is a good indicator of the proper functioning of the immune system. T cells are a category of cells that are part of the lymphoid lineage. To learn more about the various cells of the lymphoid lineage, read our new infodump! Click on the link above

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Ethnopharmacological relevance: The efficacy of immunotherapy for hepatocellular carcinoma (HCC) is often limited by an immunosuppressive tumor microenvironment (TME), largely driven by tumor metabolic reprogramming (the Warburg effect) that impairs CD8+ T cells. Targeting this metabolism to restore immunity is a promising strategy. Bie-Jia-Jian Pill (BJJP), a traditional formula for “softening…

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This is a summary of: Ogawa, C. et al. Phosphorylation of Runx protein controls helper CD4+ T cell versus cytotoxic CD8+ T cell lineage choice. Nat. Immunol. https://doi.org/10.1038/s41590-026-02441-6 (2026). Read more about this post… Credits: Source Disclaimer

Bispecific T cell engagers (TCEs) often exhibit limited efficacy in solid tumors, in part due to immunosuppressive cues in the tumor microenvironment and low expression of targetable tumor antigens. Therapeutic strategies to improve TCE target sensitivity and enhance T cell effector functions therefore have significant translational potential. Here, we engineered TCEs that induce T cell…

Klebanoff, C. A. et al. Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice. Clin. Cancer Res. 17, 5343–5352 (2011). Article  PubMed  PubMed Central  Google Scholar  Verma, V. et al. MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects. Nat. Immunol. 22, 53–66 (2021). Article  PubMed  Google…

Christo, S. N., Park, S. L., Mueller, S. N. & Mackay, L. K. The multifaceted role of tissue-resident memory T cells. Annu. Rev. Immunol. 42, 317–345 (2024). Article  PubMed  Google Scholar  Szabo P. A., Miron M., Farber D. L. Location, location, location: tissue resident memory T cells in mice and humans. Sci Immunol. https://doi.org/10.1126/sciimmunol.aas9673 (2019). Milner, J. J. et al.…

Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8+ T cells Summary Targeting STAT3 specifically in neutrophils, a type of white blood cell, significantly hinders tumor progression, according to this research. The mechanism behind this involves a boosted presence and activity of cytotoxic CD8+ T cells, immune cells crucial for directly killing…

The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion Summary Research indicates that the prostacyclin receptor, PTGIR, plays a crucial role in regulating CD8+ T cell exhaustion, a state of dysfunction that hinders effective immune responses against chronic infections and cancer. The study highlights that PTGIR expression in CD8+ T cells is dependent on NRF2, a…