#bioengineering

For the past two decades, scientists have been manipulating genes to grow human cells where you wouldn’t quite expect them. Human ears and skin have famously been grown on mice. More recently, early-stage human kidneys have even been grown in pig bellies. The world of bioengineering isn’t for the faint of heart.  Much of this tinkering is done in the service of one day using genetically modified animals to create spare organs and tissue for human patients lacking access to donors. Now, according to a study published in the journal Stem Cells Translational Medicine, researchers have shown it’s possible to cultivate lab-grown human teeth cells inside of a pig’s mouth. The researchers believe these findings could one day lead to the development of biological tooth substitutes that could be used in place of imperfect synthetic dental implants currently used. The paper’s findings were first spotted by MIT Technology Review.

C'mon, you can make an oddish if you really need to start small. We both know you're too much of a weeb to say no.

I'll have you know I am a AMAZING-- No,, BRILLIANT bioengineer, first off!! 9-10 year's of practice and effort DOES pay off! ‚:[

Second,, now that you mention it..

I could actually legitimately do that!

If I put in the effort,, of course!

.

.

.

But my ass would instantly get fired if I go off task.

I could work on it back at my apartment,, though!

Would be a bit cramped..

I think. . . If anything, I probably have some old scrapped files lying around somewhere about creating supposedly 'non-living' creatures into making them.. Well, live!

AND A POKEMON IS AN AMAZING IDEA!!

\\OOC holy nerd moment..

Simple, sweet and small! It could be a rather easy task.. If I have possible free time,, I might try looking through some scrapped files--.. They're scrapped for a reason,, but since you're so sure of yourself.. Jævla jævla. . .

A-and--

AND I'M NOT A WEEB?!

I'M ONLY DOING THIS BECAUSE I BELIEVE IT COULD WORK OUT!! N-NOT BECAUSE I'M TOO MUCH OF A 'WEEB' TO NOT DO IT?!

If you're going to be so STUCK UP about it then I might as well not even bother in doing it at all! ((//OOC he'll still 100% do it.. What a nerdy douche.. Grr. . .))

**grumble. . . grumble.. huff.. grumble. . .**

Brain Folds

A fusion of an ancient paper-folding craft and the gentle touch of acupuncture, these microscopic spikes unfold from flat sheets to form a 3D brain probe that slips into brain tissue and listens to its whispers. Most existing brain probes are flat (good for surface-level recording but lacking penetration) or rigid 3D structures (can damage tissue on entry). The spikes’ balance of strength and flexibility minimised disruption to the tissue while researchers recorded seizure-like events in human brain tissue samples and electrical responses to stimuli in living mouse brains. The developers suggest the approach is scalable so could be used for large-scale sampling of neural tissue electrical activity. This will help researchers study brain abnormal activity patterns in brain disorders such as epilepsy or Parkinson’s, and might eventually guide treatment by assessing a brain’s condition, or facilitating brain-machine interfaces to turn thoughts into action.

Written by Anthony Lewis

Image from work by Marie Jung and colleagues

Bioelectronics, Institute of Biological Information Processing-3, Forschungszentrum Jülich, Jülich, Germany

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Advanced Materials, April 2025

In-Depth Analysis of the Nomu Species, Prototypes, and Gigantomachia

Introduction

The Nomu, also known as Artificial Humans, are a pivotal antagonistic force in the My Hero Academia franchise. Created by Dr. Kyudai Garaki and All For One, these bio-engineered beings are deceased humans modified to possess multiple Quirks, rendering them powerful, mindless super-soldiers for the League of Villains and later the Paranormal Liberation Front. This analysis explores the Nomu species, their various tiers, prototypes, and the unique case of Gigantomachia, a kaiju-like villain with distinct characteristics.

Nomu Species Overview

Nomu are created from human corpses, subjected to extensive genetic modification to enhance physical capabilities and implant multiple Quirks. The process erases higher brain functions, leaving most Nomu as obedient, mindless entities that require direct orders to act. Their grotesque appearance, often featuring exposed brains and unnatural skin colors (e.g., blue, yellow, black), reflects their transformation into something barely human. The Nomu serve various roles, from expendable foot soldiers to strategic game-changers in battles, with their power scaling based on their tier and Quirks.

Creation Process

Source Material: Nomu are derived from deceased humans, with some cases (e.g., Kurogiri) indicating that corpses are as viable as living subjects.

Quirk Implantation: All For One provides multiple Quirks, which are surgically integrated by Dr. Garaki. Without All For One, Garaki can still extract and duplicate Quirks, though the process is less efficient and may yield weaker results.

Modification: The transformation involves drastic physical alterations, resulting in exposed brains, jumbled internal structures, and enhanced physical attributes. The process is shrouded in mystery, with the gruesome details left ambiguous, enhancing their horror.

Purpose: Nomu are designed as tools for the League’s goals, ranging from mass destruction to targeted missions. High-End Nomu retain some personality and intelligence, tailored for specific violent tasks.

Tiers of Nomu

Nomu are categorized into five tiers based on their strength, Quirk count, and intelligence:

Lower-Tier Nomu:

Characteristics: Light-colored skin, minimal Quirks (1-2), and enhanced physical strength. They require voice commands to act and are the weakest tier, yet capable of overpowering minor Pro Heroes.

Role: Expendable foot soldiers used for overwhelming numbers or distraction.

Example Quirks: Absorption and Release, Tongue Web, Muscle Augmentation.

Notable Instances: The white-skinned Hosu Nomu with four eyes, used during the Vs. Hero Killer Arc to wreak havoc in Hosu City.

Middle-Tier Nomu:

Characteristics: More vibrant skin colors, increased power, and additional Quirks compared to Lower-Tier. They still lack significant intelligence.

Role: Stronger support units, capable of more complex tasks but still reliant on orders.

Example Quirks: Unnamed Flying Quirk, Tool Arms.

Notable Instances: The winged Hosu Nomu with a mask-like face, involved in capturing Izuku before being killed by Stain.

Upper-Tier Nomu:

Characteristics: Black skin, Super Regeneration Quirk, and strength equivalent to ten average humans. They can contend with top Pro Heroes.

Role: Heavy hitters in critical battles, often deployed to counter strong opponents.

Example Quirks: Super Regeneration, Shock Absorption.

Notable Instances: The USJ Nomu, designed to counter All Might, and the black-skinned Hosu Nomu, killed by Endeavor’s fire.

Near High-End Nomu:

Characteristics: Incomplete High-End Nomu with phenomenal strength and speed comparable to High-Ends but lacking intelligence. They were rushed into deployment, limiting their enhancements.

Role: Mass-produced for All For One’s final conquests, overwhelming through numbers and raw power.

Example Quirks: Wing, Burst, Bone Spikes, Super Spit.

Notable Instances: Deployed during the Final War Arc to support Shigaraki, with some escaping to raid Tartarus.

High-End Nomu:

Characteristics: The pinnacle of Nomu creation, with black skin, multiple Quirks (including Super Regeneration), and retained intelligence/personality. They require stabilization time post-activation to reach full potential.

Role: Strategic assets capable of independent thought and devastating combat prowess, used to shift battle tides.

Example Quirks: Super Regeneration, Liquification, Rupture, Spatial Distortion, Muscle Augmentation.

Notable Instances: Hood, Woman, Eleph, Robot, Chubs, and Ribby, deployed during the Jaku Hospital raid and Pro Hero Arc.

Powers and Abilities

Nomu exhibit a range of abilities, primarily derived from their implanted Quirks and enhanced physicality:

Common Quirks:

Super Regeneration: Allows rapid healing, even from near-total destruction, though it fails if the brain is incinerated (e.g., by Endeavor’s Hellfire).

Muscle Augmentation: Enhances physical strength, seen in Nomu like Hood and the Four-Eyed Hosu Nomu.

Shock Absorption: Absorbs impact up to a limit, as seen in the USJ Nomu.

Warping: Enables teleportation, used by utility Nomu like Johnny and Kurogiri.

Physical Enhancements: Immense strength, durability, speed, reflexes, stamina, and endurance make Nomu formidable. High-End Nomu like Hood combine these with tactical intelligence.

Weaknesses:

Brain Vulnerability: Destroying the brain is the only reliable way to kill a Nomu, as their regeneration cannot recover from this.

Command Dependency: Lower and Middle-Tier Nomu require orders, rendering them catatonic without guidance.

Stabilization Time: High-End Nomu are weaker if deployed prematurely, as seen during the Jaku Hospital raid.

Fire-Based Attacks: Endeavor’s Hellfire can overcome regeneration by reducing Nomu to ashes.

Prototypes and Key Individuals

Kurogiri

Background: Created from the corpse of Oboro Shirakumo, a former U.A. student and friend of Aizawa and Yamada. His Cloud Quirk was combined with others to form the Warp Gate Quirk.

Role: A unique Nomu designed as a loyal caretaker for Tomura Shigaraki, capable of speech and limited free thought. Unlike other Nomu, he retains personality traits (e.g., caring nature) from his human life.

Quirk: Warp Gate allows him to create portals from his foggy body, crucial for League logistics. It’s more versatile than All For One’s Glop Warp but requires his physical presence and knowledge of locations.

Key Moments:

Acts as Shigaraki’s guardian, managing his needs and preventing capture.

Defies All For One’s orders during the Final War Arc to protect Shigaraki, teleporting heroes to aid Deku and sacrificing himself to intercept an attack.

His brief re-emergence as Oboro during interrogation provides critical information about Garaki’s hospital.

Significance: Kurogiri is a prototype for intelligent Nomu, showcasing Garaki’s early success in retaining personality while programming loyalty. His eventual rebellion highlights the limits of Nomu programming when loyalty conflicts with core directives.

USJ Nomu

Background: The first Nomu introduced, designed to counter All Might as the “Anti-Symbol of Peace.” Originally a petty thug, he was modified with four extra Quirks.

Quirks: Shock Absorption, Super Regeneration, and immense physical strength.

Role: A brute force weapon, deployed during the USJ Arc to attack Class 1-A and All Might.

Key Moments:

Nearly kills Aizawa and overpowers students, showcasing its threat level.

Defeated by All Might overloading its Shock Absorption with rapid punches, leading to its arrest.

Significance: A prototype for raw power, the USJ Nomu’s limitations (e.g., inability to act without orders) informed later Nomu designs, reducing excessive modifications to preserve functionality.

Hood

Background: One of the earliest High-End Nomu, formerly a cage fighter, retaining bloodthirsty tendencies and intelligence.

Quirks: Super Regeneration, Muscle Augmentation, Shapeshifting Arm, Shoulder Jet, Storage.

Role: A test subject for Dabi during the Pro Hero Arc, deployed to fight Endeavor and Hawks in Fukuoka.

Key Moments:

Overpowers Endeavor, causing significant destruction and scarring the hero.

Uses Storage Quirk to deploy nine weaker Nomu, showcasing tactical versatility.

Killed by Endeavor’s Hellfire after Hawks’ assistance, highlighting the brain destruction weakness.

Significance: Hood represents a successful High-End prototype, balancing intelligence with overwhelming power. His rushed deployment revealed stabilization issues, a flaw addressed in later High-Ends.

Johnny and Mocha

Background: Small, utility-focused Nomu with minimal combat ability, designed for support roles.

Quirks:

Johnny: Warping, identical to All For One’s teleportation Quirk.

Mocha: Double, sampled from Twice, used to create duplicates.

Role: Facilitate League operations, with Johnny transporting members and Mocha aiding Garaki’s subterfuge.

Key Moments:

Johnny is crushed by Mirko during the Jaku Hospital raid.

Mocha sacrifices itself to protect Garaki, demonstrating unexpected initiative for a Lower-Tier Nomu.

Significance: These Nomu highlight Garaki’s versatility in creating specialized, non-combat variants, serving as early experiments in Quirk utility.

Gigantomachia

Overview

Gigantomachia is a unique entity within the League, distinct from typical Nomu due to his size, intelligence, and loyalty-driven Quirks. A kaiju-like villain, he served as All For One’s bodyguard before being assigned to Shigaraki.

Characteristics

Appearance: A gargantuan humanoid with rocky skin, spikes, and a lantern jaw, resembling a mythical giant or kaiju.

Quirks:

Endurance: Converts morale into physical power, amplifying strength when loyal to his master.

Gigantification: Allows size increase during battle.

Pain Blocker: Nullifies pain, enhancing durability.

Fierce Gains, Dog, Mole, Energy Saver: Enhance strength, tracking, burrowing, and stamina, respectively.

Intelligence: Limited (1/6 per Ultra Analysis Book), akin to a “dim-witted beast,” but capable of speech and basic reasoning. He recognizes betrayal, as seen in his rage against All For One’s abandonment.

Loyalty: Initially exhibits blind obedience to All For One, later transferring to Shigaraki after proving worthiness. His loyalty wanes after being abandoned, leading to rebellion.

Role and Key Moments

Bodyguard: Protected All For One until reassigned as a secret weapon for Shigaraki.

Meta Liberation Army Arc: Turns a losing battle into a massacre, decimating the enemy but endangering the League due to his indiscriminate destruction.

Paranormal Liberation War Arc: Bulldozes through 20 cities to reach Shigaraki, showcasing his unstoppable nature. Sedatives only work when he lacks active orders, highlighting his command dependency.

Final War Arc: Controlled by Shinso’s Quirk to fight for the heroes, leveraging his obedience to voice commands. His rage against All For One’s betrayal persists post-brainwashing, leading to his attack on his former master. Killed by All For One’s lightning attack, splitting him in half.

Impact: His destructive rampages (e.g., terrifying Mina, overwhelming Class 1-A) cement him as “pure dread” incarnate, a physical reminder of the war’s toll.

Significance

Prototype Influence: Gigantomachia’s genome informs Nomu subservience, making him a foundational prototype for their obedience programming. His multiple Quirks and physical enhancements prefigure High-End Nomu designs.

Weaknesses:

Blind Obedience: His need for commands makes him vulnerable to Shinso’s Quirk and containment when orders are absent.

Intelligence: His limited intellect allows manipulation (e.g., by Ashido) and prevents independent strategy.

Betrayal: His loyalty, while immense, has limits, as seen in his turn against All For One.

Comparison to Nomu: Unlike mindless Nomu, Gigantomachia retains some autonomy and emotional capacity (e.g., crying over Shigaraki’s weakness). His kaiju-like scale and unique Quirks set him apart, but his command-driven nature aligns with Lower-Tier Nomu.

Analysis

Evolution of Nomu Design

Early Prototypes: Kurogiri and the USJ Nomu represent initial experiments. Kurogiri prioritizes utility and intelligence, while the USJ Nomu focuses on raw power, revealing flaws like over-modification and command dependency.

Refinement: Hood and later High-Ends address these issues by balancing intelligence with power, though stabilization time remains a hurdle. Near High-Ends sacrifice intelligence for mass production, reflecting strategic shifts in All For One’s plans.

Garaki’s Role: His ability to duplicate Quirks and tweak them (e.g., enhancing Overhaul into Decay) showcases his genius, though limitations without All For One’s direct involvement highlight their partnership’s synergy.

Strategic Importance

Battlefield Impact: Nomu, especially High-End and Gigantomachia, are game-changers. Kurogiri’s Warp Gate shifts battle dynamics, while Gigantomachia’s rampages and High-Ends’ tactical prowess overwhelm heroes.

Psychological Warfare: Their grotesque appearance and relentless nature instill fear, as seen with Mina’s trauma and Class 1-A’s realization of their vulnerability post-USJ.

Countermeasures: Heroes exploit Nomu weaknesses (e.g., brain destruction, command reliance) and develop strategies like Shinso’s brainwashing to turn assets like Gigantomachia against villains.

Ethical and Narrative Implications

Moral Horror: The Nomu’s creation from human corpses, including recognizable individuals like Oboro, underscores All For One’s and Garaki’s amorality. The use of Tsubasa (potentially Garaki’s grandson) adds a personal layer of cruelty.

Redemption Potential: Kurogiri’s partial re-emergence as Oboro and Spinner’s restoration suggest that Nomu programming can be reversed, offering hope for victims but highlighting the tragedy of their transformation.

Narrative Role: Nomu escalate the series’ stakes, transitioning from school-based conflicts to existential threats. Gigantomachia’s dread and the Nomu’s relentless power embody the villains’ growing menace, pushing heroes to their limits.

Conclusion

Living as a government asset has never left room for normal in Amy Tucker's life. And landing this recent role as FBI in an apocalyptic city, was the last thing on her bucket list. After getting confined within the RPD and witnessing its downfall, she's operating with a little more than a cracked Walkman and an empty sidearm to rely on. That is, until she runs into a certain Rookie cop who might just be the missing piece she needed.