#arfs

Inspired from doinganap's speculation on Phil having a headache while playing dream daddy; so it happens and Phil tries to keep it under wraps, a monumental one throbbing in his temples but Dan sees through his act, he always does.(sick!phan) either this or the time Dan got taken to the hospital by Phil and Phil sneaked him some burgers in as the hospital food sucked XO xo

Genetic approaches have revealed additional types of transcription factors that act downstream of ARFs to coordinate specific aspects of root growth (Figure 17.22).

The nature of these defects seen in these loss-of-function mutants suggests that the corresponding genes are required for establishing the normal apical-basal pattern (Figure 17.10). (...) The cloning of the MONOPTEROS (MP) gene (see Figure 17.10B and C) revealed that it encodes a member of a family of proteins called auxin response factors (ARFs), implicating its auxin-dependent processes. (...) mp mutants not only lack the basal region of the embryo (see Figure 17.10B and C) but also have defects in vascular patterning similar to those observed when auxin levels or movements are artificially disturbed, suggesting that MP is likely to regulate genes that guide auxin-dependent vascular development.