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Researchers from the University of Pennsylvania may have developed a vaccine for seasonal allergies and food allergies.
Y'ALL THIS IS SO COOL AND COULD BE HUGE FOR SO MANY PEOPLE
additional article:
A new Penn mRNA vaccine stopped allergens from causing dangerous immune reactions and life-threatening inflammation in mice.
BRIEF SUMMARY:
It is an mRNA vaccine with successful mammalian (mice) trials.
The vaccine targets life-threatening inflammation and immune responses.
Mice with serious allergies, which received the vaccine tailored to those allergies, stopped having immune reactions when exposed to those allergens.
Aka: vaccinating against allergies.
If they can develop it for safe human use, it could save an enormous amount of lives, and IMPROVE the lives of people who live in constant fear of encountering their lethal allergens.
Because it’s able to be tailored, and specifically affects the immune system response, it may one day be able to adjust immune responses to chronic conditions like Celiac Disease, Asthma, Food Sensitivities, Food Allergies, and potentially many other autoimmune disorders.
Imagine a future where a child with a deadly shellfish allergy could get a shot and just… not be allergic anymore. Eat shrimp with no fear.
Be born with Celiac, get a shot, and casually eat gluten with no side effects.
We’re not quite there yet, but it’s performing well in mammalian trials, and we have high hopes!
best thing about uncle iroh is that if you pay attention he is actually just as much of an idiot as zuko but has just mastered the art of coming across as a wise old man. the even better thing is that zuko is the only one on the planet who somewhat realizes this and no one would ever believe him because he's zuko
like uncle iroh 100% does dumb shit on purpose sometimes to get people to underestimate him and keep zuko from capturing the avatar, but other times he just, and i cannot emphasize this enough, does impulsive dumb shit for no reason other than the fact that terminal stupid presumably runs in the royal family's blood
uncle: "you never think things through, prince zuko!"
also uncle:
once got captured by the earth kingdom army buck ass naked bc he really wanted to go to a hot spring in enemy territory
betrayed zhao at the Northern Water Tribe with no escape plan and then spent 3 weeks starving on a boat
immediately went to a spa resort upon publicly committing treason
ate a poisonous plant and, in the spirit of Two Fish Hook Sokka, was going to solve the problem by eating another potentially poisonous plant
decided the safest place in the world they could go was the city he once FAMOUSLY laid siege to for 600 days
instead of lying low or giving a modicum of a shit about people recognizing him, overachieved himself into becoming one of the most well-known restaurant owners in said city
in fact overachieved so hard that he got an invite to meet the earth king (whose city he, again, once FAMOUSLY LAID SIEGE TO) which he fucking? accepted????
#no wonder zuko was constantly frothing at the mouth! he's the only one who knows the truth!#god just imagine the number of times people have seen zuko yelling at iroh#and assumed zuko was just being mean#when zuko was actually yelling at his uncle for wasting all their money bartering with pirates AGAIN#everyone assumes iroh is babysitting zuko but really they're pingponging responsibility back and forth#and zuko at least has the excuse of being 16#anyway I love Uncle Hypocrite so much; funniest motherfucker on the planet (via OP)
man sometimes friendship really is just "I saw this and knew it would give you psychic damage. please respond with agony" and then they do. and it's great
"Stop scrolling and please help me spread the word, because if I've landed on your page you're most likely either a black woman or someone who cares about black women and the simple phrase I'm about to share could help save a black woman's life.
Doctors are to black women what police officers are to black men. That may seem controversial but I believe it to be true and I speak from personal experience.
If you've seen this TikTok you know that a 2016 study showed that 50% of medical students and residents thought that black people couldn't feel pain the same as white people.
And we learned from this video that because of a 1999 study, to this day, there's a black correction factor for the creatinin levels in black people's kidneys, meaning we're less likely to recieve a kidney transplant if needed.
So if you go to a doctor, feel you aren't getting proper treatment or they refuse the treatment you've requested, say to them the following:
I will need you to document on record that you are refusing the treatment (or medicine) I've requested, and the reason you are doing so."
This works. I have used it in other situations. If medical staff have to document and take responsibility and be on the hook legally for doing shady shit they behave much differently.
If you weren’t already going to spread this advice because black women are at risk, then spread it because it’s applicable to everyone else as well, including you reading this.
But particularly women, and especially black women.

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I feel it would be good to have a word that's like not ragebait but shamebait, where you can read a post and just go 'ah, this person just wants me to feel ashamed of myself and is not engaging with the issue in a constructive or useful way. I do not have to participate in this actually' and like. move on with your day
Sam Handwich.
If Pikiwedia says it it must be true.
I made Pikiwedia real. Works for any Wikipedia page. Use this wisely :)
Oh, wary dell vone
Goodmorning to the Anthropic Claude AI training scraper that suddenly decided to request 660 thousand pages (exactly the number I had remaining on the starter plan) and brought Pikiwedia down.
Sudden switch from diverse user agents like chrome, safari, messenger preview to Just Claudebot. I'm not even mad though, this is maybe the funniest thing possible, because I've inadvertently poisoned their training data with thousands of fucked up articles with normal urls.
Pikiwedia perseveres, back up with a better robots.txt. I hope Anthropic has a gery vood time with Pikiwedia's data :))
“I was on a strict diet during Episode VIII, and she was like, ‘Kid, get into that fridge and take some chocolate bars. I have many there.’ And I did,” he recalls. “I failed my diet because Carrie Fisher told me to. And it [felt] great.”
-John Boyega on Carrie Fisher
This is the Carrie Fisher post of body positivity reblog for a chocolate bar from her fridge
Continue✨ Keep going✨
Thank you, lady 🤗
The Nigerian accent. God. She reminds me of home...
Always grateful when this makes the rounds

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Imagine
Imagine you’re a human - five, ten, thirty thousand years ago.
Maybe your group has been gradually domesticating/being domesticated by the local wolves.
In your valley the wild cats are living closer to the human village, then inside the human village, then inside the graineries themselves.
One day you walk by a tolerant wolf bitch nursing a litter of puppies.
An unusually calm queen with a new litter of kittens. And you see
You see one of the pups
one of the kits
was born with a white strip up its face and little white front paws.
You lose your mesolithic neolithic shit
Every member of the group gets summoned, a few at a time.
They approach the bitch
the queen
cautiously and reverently
“Look at the little white paws! That little nose!”
You are now fully domesticated.
Hey pali, concept for ya.
Paladin order that purposefully tries to forget the details of their oath, under the belief their god would prefer someone who does right because its right, rather than just 'cause they gave their word they will.
Said diety is a little confused, but gets the spirit.
Hmm. At first blush, kind of silly, doesn’t sound like it would last a generation if no one is remembering critical details of to whom, what, and why Oaths are being sworn.
But!
What about a setting where you deal with hostile forces capable of making memory and physical observation of the here and now untrustworthy, like an Old One whose physical presences causes madness, alteration of history, and the way physics and the environment works. In that case, an Oath capable of being upheld when its keeper cannot trust their own preception and memory would a be pivotal force to utilize against eldritch forces, the fixed point of light, the northern star, to guide any oathkeeping paladin through madness and unreality.
god I'm such a slut for Chinese eggplant in garlic sauce *decides it’s inaccurate to refer to myself as a slut in light of my minimal sexual activity* if The Enemy discovered my ardor for Chinese eggplant in garlic sauce, they would gain a significant strategic advantage
important reminder that most people you follow online are significantly lamer than you think they are including me. and if you feel insecure comparing yourself to someone online: DON'T. theyre probably also lame and weird. most people on the internet are
reblog if you're also lame and weird.

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my mom was trying to chew through some really tough steak and she turned to me and said “just call me The Gnawer.” she would do numbers here
she told me she doesn't remember saying this. quote, "must have been steak-induced hysteria"
happy mother's day to this crazy broad
my mom’s old house had a wood burning stove for heating and sometimes when it was cold we’d stand in front of it, but one day she was turning around in front of it so that her back and front got equally warm, and she said “just call me rotisserie Tina” and to this day Rotisserie Tina is my contact name for her in my phone
An adult male fantastic least gecko (Sphaerodactylus fantasticus) in Guadeloupe
i'm actually not sure why sphaerodactylus are often called least geckos but i have to assume its just one of the least amounts of gecko you can get
That thing's bones must be so fucking small