lauren, that's not very heterosexual of you.

Is it any wonder they miss? If a single one of these wretched conditions enters the player’s consciousness as they prepare to take their shot, they have two options: pray to God, or make kicking a stationary ball into a net twelve yards away look much, much harder than it is. You’ll see them take extraordinary care while placing the ball, like they’re doing some arcane aerodynamical work with the seams. Then they’ll back up farther than they have to, so they have space to perform a weird stutter-step run-up, as if it takes subtlety and guile to beat the keeper from this distance. Can you blame them? As I write, I’m listening to the announcers criticize Swiss center-back Manuel Akanji, who seconds ago tangoed his way to the ball just to send the shot skyward and is now doubled over with his hands on his knees like he’s about to throw up. “Just kick the ball hard into the goal,” the announcers say. “Keep it simple.”

"[Union Carbide Corporation] built the plant in Bhopal because of its central location and access to transport infrastructure. The specific site within the city was zoned for light industrial and commercial use, not for hazardous industry."

"[T]he facility [operated] with safety equipment and procedures far below the standards found in its sister plant in Institute, West Virginia."

"The local government was aware of safety problems but reticent to place heavy industrial safety and pollution burdens on the struggling industry because it feared the economic effects of the loss of such a large employer."

Among a number of other safety issues at play the night of the disaster, "The gas flare safety system was out of action and had been for three months."

"An estimated 3,800 people died immediately, mostly in the poor slum colony adjacent to the UCC plant. Local hospitals were soon overwhelmed with the injured, a crisis further compounded by a lack of knowledge of exactly what gas was involved and what its effects were."

"Immediately after the disaster, UCC began attempts to dissociate itself from responsibility for the gas leak. Its principal tactic was to shift culpability to UCIL, stating the plant was wholly built and operated by the Indian subsidiary. It also fabricated scenarios involving sabotage by previously unknown Sikh extremist groups and disgruntled employees but this theory was impugned by numerous independent sources."

"In a settlement mediated by the Indian Supreme Court, UCC accepted moral responsibility and agreed to pay $470 million to the Indian government to be distributed to claimants as a full and final settlement. The figure was partly based on the disputed claim that only 3000 people died and 102,000 suffered permanent disabilities. [...] Had compensation in Bhopal been paid at the same rate that asbestosis victims where being awarded in US courts by defendant [sic] including UCC – which mined asbestos from 1963 to 1985 – the liability would have been greater than the $10 billion the company was worth and insured for in 1984."

"At every turn, UCC has attempted to manipulate, obfuscate and withhold scientific data to the detriment of victims. Even to this date [2005], the company has not stated exactly what was in the toxic cloud that enveloped the city on that December night."

"[M]any [victims] responded well to administration of sodium thiosulfate, an effective therapy for cyanide poisoning but not MIC exposure. UCC initially recommended use of sodium thiosulfate but withdrew the statement later prompting suggestions that it attempted to cover up evidence of HCN [hydrogen cyanide] in the gas leak. The presence of HCN was vigorously denied by UCC and was a point of conjecture among researchers."

"UCC discontinued operation at its Bhopal plant following the disaster but failed to clean up the industrial site completely. The plant continues to leak several toxic chemicals and heavy metals that have found their way into local aquifers. Dangerously contaminated water has now been added to the legacy left by the company for the people of Bhopal."

"The events in Bhopal revealed that expanding industrialization in developing countries without concurrent evolution in safety regulations could have catastrophic consequences. The disaster demonstrated that seemingly local problems of industrial hazards and toxic contamination are often tied to global market dynamics."

"UCC has shrunk to one sixth of its size since the Bhopal disaster in an effort to restructure and divest itself. By doing so, the company avoided a hostile takeover, placed a significant portion of UCC's assets out of legal reach of the victims and gave its shareholder and top executives bountiful profits. The company still operates under the ownership of Dow Chemicals and still states on its website that the Bhopal disaster was "cause by deliberate sabotage"."

However angry you are about the Bhopal disaster, you're not angry enough.

Pedestrian traffic lights

The fact that we can put fluids into people via IV saves more lives than I can actually communicate. There are so, so many more ways to die when we can't do that. You can go from literally at death's door from an illness you have no other cure for, to Basically Fine, You'll Feel Icky A Bit Longer But You're Otherwise Fine and Your Own Immune System Will Work Now, from sterile saline into a vein.

Or even fucking subcutaneous, under your skin. It still gets into your system faster and bypasses any fuckery going on in your gi-tract.

But you want the other end?

I recently got the answer to a crapload of symptoms of mine and it turned out to be Crohn's. Ileal crohn's.

For most of human history there was literally nothing to do about this but hope and pray that your immune system didn't decide to rip ulcers and lesions in your digestive tract to the point where you bled out, or the point where parts of it died and killed you with sepsis, or enough to build up stricture bands of scar tissue sufficiently to cause impactions or any other really gnarly and unpleasant ways you can die because for some reason your body decides the walls of your digestive tract are the enemy and need to be dismantled cell by cell. (Including a fuckload of cancers caused by the constant damage to the cell wall.)

Even as recently as when most of the younger people reading this were small children, mostly all you could do about it was take corticosteroids when you were in a flare. And that was better than Nothing. But at the same time, corticosteroids have a potential laundry list of side effects and you want to take them as little as possible and for as brief a period as possible. And there wasn't a lot else.

I am on a medication with the proprietary name "Skyrizi" and the generic name risankizumab. It's made from taking antibodies from a non-human source and then modifying their protein sequences to be more similar to human antibodies, after which they modify them further in order to make it so that the literal only thing they do is go into my body and bind to something called "tumour necrosis factor" so that this will stop flagging my own goddamn digestive system walls for destruction by the rest of the immune system.

Please feel free to read that paragraph over again.

There used to be a common, horrific illness that sailors would get, which was mysteriously cured by limes. People know about this one, it's scurvy. But there are other horrible ways to be sick from vitamin deficiency that weren't considered curable at all, and people had no idea what caused them.

Rickets is a disease caused by vitamin D deficiency where your bones get bendy and grow in the wrong shape (it is most apparent in children). It causes permanent deformity and very easy fractures, along with debilitating pain and persistent dental issues. Historically, it was known that milk, and later, cod liver oil, would improve or prevent it, but the reason was not understood until the vitamin was discovered.

Wernicke-Korsakoff syndrome is a complication of alcoholism that leads to psychosis, dementia, and death if left untreated. Severe alcoholics used to just go completely mad before dying, basically. It ultimately results in permanent memory loss (retrograde amnesia), as well as the inability to form new memories (anterograde amnesia). It is caused by the fact that alcohol prevents the absorption of vitamin B1 (thiamine). It is treatable and preventable by giving the patient thiamine shots - if caught early, before permanent brain damage has occurred, it is fully reversible, although the underlying substance abuse issue still needs to be addressed to prevent recurrence.

Pernicious anemia is caused by vitamin B12 deficiency (in turn ultimately caused by an autoimmune issue causing poor absorption). It causes blood cells to be the wrong size and too few in number, resulting in dizziness and fatigue. It also causes neurological symptoms like tingling in the extremities, poor coordination, confusion, and, in late stages, dementia. There was no cure for pernicious anemia in the past. People would simply become anemic and die from it. That's why it's called "pernicious" - that's an old-fashioned way to say "insidious and deadly," named for its slow onset and then-incurable course. Now it is curable with vitamin tablets or periodic injections.

Cretinism, or, less stigmatizingly, congenital hypothyroidism due to iodine deficiency, is a developmental disorder caused by the inability of the thyroid gland to function properly without sufficient iodine. it causes short stature, intellectual disability, infertility, hair loss, and a large lump in the neck known as a goiter (i.e. a hypertrophic thyroid gland). It was historically associated with poor inland populations living far from the ocean (due to the protective effect of consuming seafood, which is naturally high in iodine). We now simply put iodine in table salt, and this disorder is virtually unheard of in regions where this is the case.

Neural tube defects are a leading cause of birth defects, infant mortality, and stillbirth. The most common nonlethal forms of neural tube defects include spina bifida, hydranencephaly, and encephalocele. These defects are caused by a failure of the embryonic structure that becomes the spinal canal to close properly during development, leading the central nervous system to have a distorted shape that may impair cerebrospinal fluid drainage and put pressure on the brain. In severe cases, e.g. anencephaly, the brain/spine essentially develop outside of the body, which is not compatible with life (anencephalic and iniencephalic babies typically die within hours or days; fetuses with more severe forms are usually stillborn if they are not terminated). The risk of these defects is drastically reduced by taking supplemental folic acid (vitamin B9).

Vitamin K is perhaps the most amazing one on this list. Newborns often have very low vitamin K levels due to the fact that it does not cross the placental barrier easily and is not found in high levels in breast milk. It is only produced by gut bacteria, which babies do not have when they are born, and it takes time for them to acquire the right flora from their environment. Deficiency impairs blood clotting, and in infants, can lead to brain bleeds and sudden, unexplained death. Tiny babies would simply die of brain hemorrhaging for no good reason at all. But if they're given a quick shot of vitamin K at birth, that doesn't happen.

"Just making sure you're not gonna disappear for another six years."

2.03 Do The Right-est Thing Ted Lasso [2020 -]