If you feel like this is calling you out, and you're wondering how else to react instead, may I suggest focusing not on this topic that you're not interested in (because faking interest is something a lot of people can catch up on) but on the person's interest in and of itself.
"It's great that you're so into this - how did that happen?" shows interest in the person and allows them to tell you about themselves. And maybe you'll find something to connect to in their journey.
"I bet all this knowledge can come in handy at some point. Like, I'd ask you to be my game show phone joker on this topic!" Is a lovely compliment and still also gets across that you don't know much about that topic. It also opens a different tangent, that of gameshows, or topics you (or others around the table) don't know much about, so the conversation might shift from the topic you're not interested in to other places.
"Hey, sorry, I don't know much about this thing; it never really caught my attention. But it's great that you're so into it!" Can be a way to express your disinterest in a way that neither insults the other person nor shames them for being into that topic. It is a very subtle signal that you might be disinterested in hearing more, and by "subtle" I mean that not everyone will pick up on it for sure. But it's miles better than simply changing the topic.
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