Froehliche Leben!

High tech ‘smart’ pajamas that monitor heartbeat, breathing and sleep posture to give you the perfect night’s rest could soon be available, scientists have revealed. Within two years the 'smart’ nightwear could monitor and help improve sleep. 

The key to the ‘smart’ pajamas is a process called reactive vapor deposition, according to the findings presented at the American Chemical Society (ACS) Spring 2019 National Meeting and Exposition. This method allows to synthesize a polymer and simultaneously deposit it directly on the fabric in the vapor phase to form various electronic components and, ultimately, integrated sensors. Unlike most electronic wearables, the vapor-deposited electronic polymer films are wash-and-wear stable, and they withstand mechanically demanding textile manufacturing routines.

From love and politics to health and finances, humans can sometimes make decisions that appear irrational, or dictated by an existing bias or belief. But a new study from Columbia University neuroscientists uncovers a surprisingly rational feature of the human brain: A previously held bias can be set aside so that the brain can apply logical, mathematical reasoning to the decision at hand. These findings highlight the importance that the brain places on the accumulation of evidence during decision-making, as well as how prior knowledge is assessed and updated as the brain incorporates new evidence over time.

This research was reported in Neuron.

“As we interact with the world every day, our brains constantly form opinions and beliefs about our surroundings,” said Michael Shadlen, MD, PhD, the study’s senior author and a principal investigator at Columbia’s Mortimer B. Zuckerman Mind Brain Behavior Institute. “Sometimes knowledge is gained through education, or through feedback we receive. But in many cases we learn, not from a teacher, but from the accumulation of our own experiences. This study showed us how our brains help us to do that.”

“When we look hard under the hood, so to speak, we see that our brains are built pretty rationally. Even though that is at odds with all the ways that we know ourselves to be irrational.”

As an example, consider an oncologist who must determine the best course of treatment for a patient diagnosed with cancer. Based on the doctor’s prior knowledge and her previous experiences with cancer patients, she may already have an opinion about what treatment combination (i.e. surgery, radiation and/or chemotherapy) to recommend — even before she examines this new patient’s complete medical history.

But each new patient brings new information, or evidence, that must be weighed against the doctor’s prior knowledge and experiences. The central question, the researchers of today’s study asked, was whether, or to what extent, that prior knowledge would be modified if someone is presented with new or conflicting evidence.

To find out, the team asked human participants to watch a group of dots as they moved across a computer screen, like grains of sand blowing in the wind. Over a series of trials, participants judged whether each new group of dots tended to move to the left or right — a tough decision as the movement patterns were not always immediately clear.

As new groups of dots were shown again and again across several trials, the participants were also given a second task: to judge whether the computer program generating the dots appeared to have an underlying bias.

Without telling the participants, the researchers had indeed programmed a bias into the computer; the movement of the dots was not evenly distributed between rightward and leftward motion, but instead was skewed toward one direction over another.

“The bias varied randomly from one short block of trials to the next,” said Ariel Zylberberg, PhD, a postdoctoral fellow in the Shadlen lab at Columbia’s Zuckerman Institute and the paper’s first author. “By altering the strength and direction of the bias across different blocks of trials, we could study how people gradually learned the direction of the bias and then incorporated that knowledge into the decision-making process.”

The study, which was co-led by Zuckerman Institute Principal Investigator Daniel Wolpert, PhD, took two approaches to evaluating the learning of the bias. First, implicitly, by monitoring the influence of bias in the participant’s decisions and their confidence in those decisions. Second, explicitly, by asking people to report the most likely direction of movement in the block of trials. Both approaches demonstrated that the participants used sensory evidence to update their beliefs about directional bias of the dots, and they did so without being told whether their decisions were correct.

“Originally, we thought that people were going to show a confirmation bias, and interpret ambiguous evidence as favoring their preexisting beliefs” said Dr. Zylberberg. “But instead we found the opposite: People were able to update their beliefs about the bias in a statistically optimal manner.”

The researchers argue that this occurred because the participants’ brains were considering two situations simultaneously: one in which the bias exists, and a second in which it does not.

“Even though their brains were gradually learning the existence of a legitimate bias, that bias would be set aside so as not to influence the person’s assessment of what was in front of their eyes when updating their belief about the bias,” said Dr. Wolpert, who is also professor of neuroscience at Columbia University Irving Medical Center (CUIMC). “In other words, the brain performed counterfactual reasoning by asking ‘What would my choice and confidence have been if there were no bias in the motion direction?’ Only after doing this did the brain update its estimate of the bias.

The researchers were amazed at the brain’s ability to interchange these multiple, realistic representations with an almost Bayesian-like, mathematical quality.

“When we look hard under the hood, so to speak, we see that our brains are built pretty rationally,” said Dr. Shadlen, who is also professor of neuroscience at CUIMC and an investigator at the Howard Hughes Medical Institute. “Even though that is at odds with all the ways that we know ourselves to be irrational.”

Although not addressed in this study, irrationality, Dr. Shadlen hypothesizes, may arise when the stories we tell ourselves influence the decision-making process.