Just a thought BUT Enid got accepted into her pack and got with Bruno after she wolfed out. If she hadn't wolfed out in Season 1, they never would've let her in, right ? And I'm pretty sure Enid is aware of that. In the pack, even after she wolfed out, there is still this divide between her and others because she got in much later. She only recently got the opportunity to hang out with them and form friendships with other members.
So, in Enid's mind they're not as close to her as Wednesday is, and none of her new friends could replace Wednesday simply because they didn't embrace her before she wolfed out.
However, she didn't see a reason why Agnes couldn't replace her. Agnes embraced all of Wednesday's traits that made her an outcast within outcasts, which is something the pack and Bruno clearly did not do for her. In Enid's mind, Wednesday and Agnes could be as close, if not closer, as she and Wednesday had been.
Plus she probably didn't even think about the fact that maybe Wednesday also felt replaced by her. She knew that the pack and Bruno could never replace Wednesday as a friend or as a potential love interest. That's why when she tried to call out Wednesday for replacing her and Wednesday said You're a little preoccupied (as in spending all her time with Bruno and the pack) she didn't see her fault in spending time with them because she assumed Wednesday could never feel replaced by them. So, she assumed it was all on Wednesday who apparently didn't want to spend time with her or be her friend anymore.
I'm living for this miscommunication !!