Effects of Vitamin D on vascular function
http://odishasamaya.com/news/health/effects-of-vitamin-d-on-vascular-function/63164
Nutritional Vitamin D supplementation improves the vascular function and reduces inflammation in early stage of chronic kidney disease, a study has revealed.
It stated that no other medicine has proper effect in the inflammation of kidneys or any other problems related to it.
In a randomised controlled trial under direct supervision of the researchers, two ground were created of 60 patients each.
“Vitamin D deficiency is common in patients with chronic kidney disease. Our study shows that simply identifying and correcting this abnormality has the potential to improve the outcomes in these patients,” said Vivek Kumar, nephrologist at the Chandigarh institute and the first author of the study.
About one in 10 people suffer from chronic kidney disease around the world. Most of these patients are destined to develop premature cardiovascular disease, said Vivekanand Jha, leader of the study group.
In a randomised controlled trial under direct supervision the researchers gave two doses of 3, 00,000 units of Vitamin D to one group of patients eight weeks apart whereas the patients in the other group received matching placebo.
Vitamin D is cheap and widely available, and through its favorable effects on inflammatory and immune functions, it has the potential to favorably influence the outcome in these patients, said the researchers.
“This study has shown improvement in a range of parameters in Vitamin D-treated patients. What makes this finding of special importance is that patients in both groups were already on optimal treatment to reduce cardiovascular risk, hence the benefit of Vitamin D was additive,” Jha added.
About 70 percent of patients receiving Vitamin D demonstrated significant improvement in their vascular functions and improvement in biomarkers indicating reduction in the level of inflammatory and immune activation.
In the placebo arm, only 5 percent patients showed improved vascular function and there was no change in the inflammatory and immune markers. Neither the patients nor the study doctors were aware of which patients received which treatment till the conclusion of the study, the researchers said.
