#uridine

The Benefits Of Taking Uridine – Credihealth Blog

A piece of ribonucleic acid (RNA), uridine has the ability to deliver a number of different health benefits to those people who take it. Some of these are detailed below in greater detail so that you can determine if it is something that is worth taking for you. Nerve Damage & Pain The evidence from clinical trials shows that when uridine is combined with the vitamin B12 and folic acid, it can…

Authored by  Krishnan V*

Abstract

Antimetabolites 5-Fluorouracil and capecitabine are used in many cancers including breast, colon, anal canal, etc. Toxicity of these agents is mild to severe and may be fatal, toxicity more common in high dose chemotherapy and patients with dihydropyromidine deficiency patients. Uridine triacetate approved as first ever chemoprotectant molecule to prevent 5-Fluorouracil and capecitabine toxicity.

Keywords: Flurouracil overdose; capecitabine adverse effects; chemoprotectant; uridine triacetate

Introduction

5 -Flurouracil (5-FU) is one the common anticancer drug belonging to antimetabolite category. Its Anatomical Therapeutic Calcification code is L01BC02 and its chemical formula is C4H3FN2O2. It is S phase specific agent, affects DNA synthesis and replication. It inhibits thymidylate synthesis enzyme and thereby conversion of deoxyuridine monophosphate to thymidine triphosphate.

Since its introduction in cancer chemotherapy, 5-FU used in various cancers. Currently it's a part of gastric cancer, breast cancer, colon cancer (FOLFOX regimen-Flurouracil, leukovorin, oxaliplatin) and (FOLIRNOX regimen-flurouracil, leukovorin, irinotecan, oxaliplatin) etc . Its congeners, floxuridine used intra-arterially in hepatic metastasis and capecitabine used in recurrent breast colon and breast cancer. 5-FU as a neoadjuvant therapy along with irradiation used in anal cancer, premalignant skin conditions and basal cell carcinoma, Adverse effects of 5-FU are considerable; they are severe gastric ulceration and fatal mucosal bleeding, severe leukopenia, hand foot syndrome, acute myocardial damage and acute cerebellar toxicity. 5-FU is one the low therapeutic index agent and requires careful precise intravenous administration. Toxic effects can be seen in normal individuals and more severe in patients with dihydropyrimidine dehydrogenase deficiency with more than eight percent mortality [1].

Uridine triacetate; clinical trials and FDA approval

This drug was granted approval by United states-Food and drug administration (US-FDA) as an orphan drug for patients with documented 5-FU toxicity or those who are exposed to high dose of 5-FU. It should be administered within 96 hours of signs and symptoms for optimum benefits. This molecule was evaluated in two trials comprising adult and pediatric patients of 135 sample sizes who were exposed to 5-FU or capecitabine and developed signs of toxicity. Success rate was more than ninety percent than the historical control where 5-FU toxicity mortality was severe and mortality rate was about 80 -85 percent [2] (Figure 1).

Uridine Triacetate; Pharmacodynamics

5-FU is converted in the body as as triphosphate derivative (FUTP). This derivative combines with ribonucleic acid (RNA) and form toxic intermediates which cause cell cycle arrest. Uridine from urdine triacetate is competitive to FUTP incorporation and thereby prevents the formation of toxic intermediates [3].

Uridine Triacetate; Clinical Pharmacokinetics

Its chemical formula is C15H18N2O9. It triacetate can be administered orally and available as oral granules in a sachet. It is s prodrug converted into active form by deacetylation and concentration maximum is attained is within two to three hours and it is also excreted faster from the body with a half of 4.5-5 hours. Dose for adults is 10g every 6 hours, can be given fifteen to twenty doses and pediatric dose must be calculated based on standard formula 6g/m2. It does not cause renal and hepatic impairment and can be used safely in renal or hepatic insufficiency patients; however there no evidence available till date to support its use in pregnancy and lactating mother [3].

UridineTriacetate; Post Marketing Status

Post marketing surveillance did not receive any serious adverse effects uridine triacetate. The common side effects are vomiting diarrhea and mild rashes. Wa, et al. [4] a leading gastrointestinal oncologist recently said on GI cancers and drug development program at San Francisco, Uritidine triactetae is expected to reduce more than ninety five percent of deaths from 5-Fu or capecitabine grade 3 to grade 5 toxicity. Few other reports are also encouraging the use of uridine triacetate [4-6]

Conclusion

Uridine triacetate discovery tends to ameliorate all theadverse effects of 5-FU without compromising its efficacyenables more efficient use of 5-FU with good patient compliance.

To Know More About Journal of Biomedical Engineering  Please Click on:

https://juniperpublishers.com/ctbeb/index.php

In this post, I will briefly touch upon what the Uridine Stack is, what it’s supposed to do, my experiences with it, and a couple tips you might need should you decide to try it out. The Uridine Stack has become one of the more talked-about stacks on Reddit and throughout the net with many favorable reviews.

What does the Uridine Stack benefit?

According to the original thread at Longecity containing dozens and dozens of sources that one could spend a couple of hours trawling through1, the Uridine Stack can supposedly benefit the following over the short term and long term:

Improved and stabilized mood

Reducing stress and anxiety

Modulating or stabilizing dopamine release

Improvement of sleep and sleeping patterns

Tons of other benefits to brain, cellular, mitochondrial and neuron health

Reportedly uridine can also potentiate the effects of stimulants such as caffeine or nicotine, but one Reddit thread has found this to be a little implausible or at least not true in their experiences.2

What is Mr. Happy’s Uridine Stack?

“Mr. Happy” is the username of the Longecity poster that first devised this stack and collected the research behind it. He has been taking one form of the stack or another since its inception c. 2011.

Most variants of the stack include some form of uridine, fish oil and a choline source that can cross the blood-brain barrier. Adjuncts like folate (vitamin B9) and vitamin E are also suggested, folate in particular as uridine accelerates RNA synthesis and this process may use up additional vitamin B9.

The uridine is reportedly the workhorse behind the stack and is associated with many of the benefits reported by people who take it.

Where to get the Uridine Stack

You can easily make your own, you just need a form of uridine, fish oil and some form of choline.

Powder City has the Uridine Stack for just $21.95, including a 30-day supply of fish oil caps and Alpha-GPC caps

Uridine Monophosphate (UMP) or Triacetyluridine (TAU)?

Uridine Monophosphate is the type included in Powder City’s stack and seems to be the more commonly used variation of uridine that is water-soluble and can (and should, in my opinion) be taken sublingually. Sublingual doses are reportedly much stronger than oral, as in the case of Noopept. I like this one since you can titrate the dosage as desired.

Triacetyluridine is lipid-soluble form of uridine and is not absorbed very well sublingually. However, its oral bioavailability is much better than UMP. You may want to take this one with a little fatty food or oil. Good if you don’t want to hold the stuff under your tongue for a few minutes.

How to take the Uridine Stack

Here are MrHappy’s recommendations straight from the thread3 (formatted by me):

For the first 2 weeks:

150-250mg UMP, orally, twice per day

A *good* multi vitamin, that includes RDA of B-group Vitamins and a broad range of trace minerals, including magnesium

500IU of mixed vitamin E [ed. – already in the above link]

A large dose of fish oil with >700mg DHA + >300mg EPA (or 3000mg ALA / flaxseed oil, if you are vegetarian)

After 2 weeks:

Slowly introduce choline – start with 50mg of eg. alpha-GPC [ed. – already included in Powder City’s stack] or CDP-choline and ramp it up to around 300mg.

If you experience depressive symptoms from choline, discontinue choline and consider ALCAR as an alternative.

When taking Uridine Monophosphate (UMP) sublingually, I hold the stuff under my tongue for up to 10 minutes. Most of the flavor should be gone save for any undissolved powder that may have settled.

My initial experiences with the Uridine Stack

When I first got the Uridine Stack from Powder City, admittedly I only ordered it because it was new to me. Through skimming, I knew none of the components were unsafe in the recommended doses, but I had no idea what it was meant to benefit and only took a first dose before learning more about it. (Hence the importance of always doing your research.)

Every time I take the uridine (UMP) sublingually, I notice that it tends to clear out any brain fog very effectively within the hour. Mood and motivation tend to be made very stable for the following 4 to 6 hours. Because of the apparent short-term effects, I could see uridine on its own becoming a mainstay in my daily supplement regimen.

The fish oil on its own is good to have in general4, as most of us do not get enough Omega-3 in our diets to begin with. The benefits of Omega-3 fatty acids seem to be more long-term than short-term, but the piles of research out there already support taking it.

I unfortunately did not heed the warning to take the Alpha-GPC after two weeks. I took it the first day and decided to leave it out after a while as it did not help me. I will need to restart the regimen with this and see how it goes, because I believe the Alpha-GPC can mess up my mood. Your mileage may vary however.

I was not worried about the B vitamins (specifically the folate/vitamin B9) or the trace minerals as I already get some form of those through supplements and/or juicing as of late.

I also did not notice any changes in sensitivity to stimulants when taking uridine, bearing in mind that I am already fairly sensitive and maintain a low tolerance to them.

Final Thoughts

The Uridine Stack is an excellent concept with plenty of sound reasoning and research to back its theories, and I believe that in spite of all the additional research that it requires before it could be considered as an actual treatment, its reception has been overwhelmingly favorable and has anecdotally yielded plenty of the benefits that research on uridine and the other stack components have suggested it would.

Original Longecity thread by Mr. Happy – GPC (choline), Uridine, DHA ↩

uridine vs. caffeine : Reddit Nootropics board ↩

Mr. Happy’s original post with dosage instructions ↩

Fish Oil – Examine.com ↩

My Experience with Mr. Happy’s Uridine Stack for Mood and Memory appeared first on Pill Scout.

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