#study 329

Study 329 – The Flawed, Fraudulent Study That GSK Used to Get Paxil Approved For Children

https://study329.org/ The International Journal of Risk and Safety in Medicine Publishes Study 329 Continuation Phase Journal of the American Association for Child and Adolescent Psychiatry (JAACAP) turns down publication Toronto (September 16, 2016) —— Study 329 had an 8-week acute phase and a further 24 week continuation phase. After 8 weeks the participants had an option to enter a further…

Dr. David Healy writes for Mad in America:

While making money from the publication of pharmaceutical company trials, and in the face of a complete failure by industry to adhere to basic scientific norms and make data available, BMJ and other journals — although BMJin particular — have run a series of articles on supposed Academic Fraud. These articles feature instances of fraud sometimes as…

Dr. David Healy writes for Mad in America:

While making money from the publication of pharmaceutical company trials, and in the face of a complete failure by industry to adhere to basic scientific norms and make data available, BMJ and other journals — although BMJin particular — have run a series of articles on supposed Academic Fraud. These articles feature instances of fraud sometimes as…

Today’s quote: conflicting interests

[ . . . ] “Science needs conflicting interests – financial and non-financial. Problems don’t get solved unless someone is motivated for some reason. We need the bias that pharmaceutical companies bring to bear in their defense of a product, along with the bias of those who might have been injured by a treatment.  Both of these biases can distort the picture, but it’s when people with differing…

Today’s quote: conflicting interests

[ . . . ] “Science needs conflicting interests – financial and non-financial. Problems don’t get solved unless someone is motivated for some reason. We need the bias that pharmaceutical companies bring to bear in their defense of a product, along with the bias of those who might have been injured by a treatment.  Both of these biases can distort the picture, but it’s when people with differing…

—

Over 70% of paroxetine studies registered at ClinicalTrials.gov (completion date before January 1st, 2011) remain unpublished.

http://www.bmj.com/content/347/bmj.f6754/rr/816737

—

—

– Study 309/248: Open Data –

— Study 309/248: Data Wars (backfire) —

… – …

— To be continued —

Paroxetine Study 309/248

WHO ICTRP: “309 records for 248 trials found for: paroxetine” — Over 70% of paroxetine studies registered at ClinicalTrials.gov (completion date before January 1st, 2011) remain unpublished.

—

Over 70% of paroxetine studies registered at ClinicalTrials.gov (completion date before January 1st, 2011) remain unpublished.

http://www.bmj.com/content/347/bmj.f6754/rr/816737

—

—

– Study 309/248: Open Data –

— Study 309/248: Data Wars (backfire) —

… – …

— To be continued —

“Neither paroxetine nor high dose imipramine showed efficacy for major depression in adolescents, and there was an increase in harms with both drugs.”

Abstract

ObjectivesTo reanalyse SmithKline Beecham’s Study 329 (published by Keller and colleagues in 2001), the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with unipolar major depression. The reanalysis under the restoring invisible and abandoned trials (RIAT) initiative was done to see whether…