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Aromatic halides occupy a foundational position in modern organic synthesis, and among them, 1,3,5-Tribromobenzene (CAS No. 626-39-1) continues to stand apart as a compound of enduring industrial and scientific significance. Its symmetric trihalide structure gives it exceptional utility as a coupling scaffold, making it indispensable across pharmaceutical API development, agrochemical synthesis, advanced material science, and specialty polymer research. As chemical manufacturing grows increasingly precision-driven, the demand for high-purity 1 3 5 tribromobenzene has only intensified across India and international markets alike. 

The Chemical Profile and Industrial Relevance of 1,3,5-Tribromobenzene 

Understanding why this compound commands sustained procurement interest begins with its molecular architecture. With a molecular weight of 314.8 and three bromine atoms positioned symmetrically on the benzene ring, it offers a degree of structural predictability that is rare among halogenated aromatics. This symmetry translates directly into reproducible multi-step reaction outcomes, which is critical for both R&D environments and large-scale production facilities working under tight quality mandates. 

The 1 3 5-tribromobenzene solubility profile is another technically important characteristic. It is sparingly soluble in water but dissolves well in common organic solvents such as chloroform, dichloromethane, and THF, making it highly compatible with standard laboratory and industrial process chemistries. This solubility behaviour influences reaction design decisions across pharmaceutical and agrochemical workflows, where solvent selection directly impacts yield and purity. 

Synthesis routes are equally relevant for procurement and process chemistry teams. The well-documented pathway for producing 1 3 5-tribromobenzene from benzene involves controlled electrophilic aromatic bromination using bromine in the presence of Lewis acid catalysts such as iron or aluminum bromide. The sequential substitution chemistry, governed by the deactivating and meta-directing effect of bromine, naturally favours the 1,3,5-substitution pattern, enabling efficient and scalable manufacturing. 

The compound's utility extends to its role as a symmetrical trifunctional platform in Suzuki-Miyaura, Kumada, and Negishi cross-coupling reactions, where it enables the construction of star-shaped or dendritic molecular architectures used in organic electronics, liquid crystals, and advanced functional materials. 

Key Application Sectors and Demand Drivers Across India and Global Markets 

The 1 3 5 tribromobenzene uses are distributed across a wide range of high-value industries, each with distinct technical requirements and procurement volumes. 

Pharmaceutical API Synthesis: Research chemists and API manufacturers use it as a trifunctional building block to introduce bromine-bearing aromatic cores into drug candidate structures. Its halogenated framework supports metal-catalysed coupling reactions essential to modern medicinal chemistry pipelines. 

Agrochemical Development: Herbicide and pesticide active ingredient manufacturers incorporate brominated aromatic intermediates at key stages of molecule construction. The compound's structural symmetry makes it particularly valuable for building multi-substituted ring systems found in high-performance agrochemical formulations. 

Material Science and Organic Semiconductors: Research teams working on organic light-emitting diodes (OLEDs), liquid crystal display materials, and organic photovoltaic systems rely on 1,3,5-tribromobenzene as a branching scaffold for synthesising star-shaped conjugated molecules with precisely engineered electronic properties. 

Contract Research and CRO Laboratories: Contract research organisations working across therapeutics, crop sciences, and functional materials depend on consistent supply of high-purity intermediates to maintain project timelines and analytical integrity. 

Academic and Government Research: Institutions affiliated with CSIR, IIT, and IICT are active users of this compound in fundamental and applied chemistry research programmes addressing synthetic methodology, catalysis, and materials innovation. 

From the perspective of the 1 3 5 trifluorobenzene market and related halogenated aromatics, growing investments in specialty chemical manufacturing across India's MIDC TTC corridor, Ankleshwar-Jhagadia in Gujarat, Hyderabad's Patancheru-Genome Valley pharma belt, and Pune's Bhosari and Chakan MIDC clusters are generating sustained and expanding demand for high-grade tribromobenzene intermediates. 

Why Purity, Reliability, and Supply Consistency Define Procurement Decisions 

In specialty chemical procurement, the technical grade of an intermediate directly determines downstream process efficiency. For a compound as structurally specific as 1,3,5-Tribromobenzene, impurities in the form of mono- or di-brominated congeners can significantly compromise reaction selectivity, reduce coupling yields, and introduce variability into multi-step synthesis sequences. This makes supplier qualification a critical decision for procurement managers and process chemists working in regulated or semi-regulated environments. 

When precision chemistry demands an uncompromising building block, research teams and industrial manufacturers across India and the globe turn to SARA Research & Development Centre (SRDC) for high-purity 1,3,5-Tribromobenzene (CAS No. 626-39-1). With a molecular weight of 314.8, this symmetrically substituted aromatic trihalide is a critically valued intermediate in advanced organic synthesis, enabling complex multi-step reactions with consistent, reproducible results. Its symmetric bromine substitution pattern makes it an exceptionally versatile coupling partner and scaffold for constructing complex molecular architectures used across material science, pharmaceutical synthesis, specialty agrochemicals, and textile chemistry. 

The demand for high-grade 1 3 5 tribromobenzene is concentrated across India's most active chemical and pharmaceutical manufacturing belts. From the MIDC TTC corridor in Rabale and Thane-Belapur to the Tarapur industrial estate in Boisar, Mumbai's extended chemical hub generates consistent procurement activity from specialty chemical manufacturers, pharma API units, and polymer research teams. Further afield, Ankleshwar and Jhagadia in Gujarat's Bharuch district, India's single largest concentration of bulk and specialty chemical production, represent a major consumption centre for brominated aromatic intermediates used in API pipelines and agrochemical synthesis. Hyderabad's Patancheru-Genome Valley pharma corridor, Pune's Bhosari and Chakan MIDC clusters, and the Baddi-Haridwar pharmaceutical belt in North India add further layers of strong, sustained demand across end-use sectors. 

The key buyers of 1,3,5-Tribromobenzene span a wide cross-section of science-driven industries: pharmaceutical R&D and API manufacturers leveraging its halogenated structure for drug intermediate synthesis, agrochemical producers incorporating it into herbicide and pesticide active ingredient frameworks, material science laboratories exploring its utility in organic semiconductors and liquid crystal applications, and contract research organisations (CROs) that depend on consistent purity and reliable supply to meet client timelines.

Academic institutions affiliated with bodies such as CSIR, IIT, and IICT are also active end-users of this compound in fundamental and applied research programmes. 

Backed by over three decades of expertise in chemical research, development, and manufacturing, SRDC delivers 1,3,5-Tribromobenzene at lab-grade purity standards that meet the rigorous demands of both R&D environments and large-scale production facilities.

Headquartered at the MIDC TTC cluster in Rabale, Navi Mumbai, one of India's most prominent chemical manufacturing hubs, it combines world-class quality control with deep process chemistry know-how to ensure every batch meets exacting specifications.  

Whether you are developing next-generation materials, synthesising pharmaceutical intermediates, or scaling up agrochemical formulations, SARA Research & Development Centre (SRDC)'s 1,3,5-Tribromobenzene is the reliable, research-backed choice that procurement teams and process chemists across India trust.

Enquire today and experience the SARA Research & Development Centre (SRDC) difference, where scientific rigour meets seamless supply, from Navi Mumbai to the world. 

Conclusion 

For chemical manufacturers, pharmaceutical API developers, agrochemical producers, and research laboratories that require a consistent, high-purity symmetrical trihalide intermediate, 1,3,5-Tribromobenzene remains one of the most technically versatile and strategically important compounds available today. Whether you are optimising a cross-coupling reaction, scaling an agrochemical synthesis, or engineering advanced functional materials, the quality and reliability of your supply source determines the success of your outcomes. Contact SARA Research & Development Centre (SRDC) today to discuss your requirements, request technical documentation, or place a procurement enquiry for high-purity 1,3,5-Tribromobenzene delivered from Navi Mumbai to your facility, wherever in the world you operate. 

Frequently Asked Questions (FAQs) 

Q1. What is 1,3,5-Tribromobenzene and what is its CAS number?  1,3,5-Tribromobenzene is a symmetrically substituted aromatic compound with three bromine atoms positioned at the 1, 3, and 5 positions of the benzene ring. Its CAS number is 626-39-1 and its molecular weight is 314.8. 

Q2. What are the primary uses of 1,3,5-Tribromobenzene in industry?  It is widely used as a trifunctional building block in pharmaceutical API synthesis, agrochemical active ingredient development, organic semiconductor research, OLED material development, liquid crystal chemistry, and contract research applications involving cross-coupling reactions. 

Q3. How is 1,3,5-Tribromobenzene synthesised from benzene?  The standard synthesis involves electrophilic aromatic bromination of benzene using bromine and a Lewis acid catalyst such as ferric bromide or aluminium bromide. The deactivating and meta-directing properties of bromine favour sequential substitution at the 1, 3, and 5 positions. 

Q4. What is the solubility profile of 1,3,5-Tribromobenzene?  It has low solubility in water but dissolves readily in common organic solvents including chloroform, dichloromethane, and tetrahydrofuran (THF), making it compatible with a wide range of laboratory and industrial process chemistry protocols. 

The Smart Guide to Chemical Sourcing for R&D Labs: Why India Is the New Sourcing Destination 

India's research and development ecosystem is expanding rapidly, and the way laboratories manage their procurement is evolving with it. Chemical sourcing for R&D labs is no longer a back-office function. It is a strategic decision that directly influences research timelines, data quality, and regulatory outcomes. Laboratories working in drug discovery, clinical diagnostics, and biotechnology need suppliers who deliver verified purity, complete analytical documentation, and consistent batch quality every single time.  

Indian speciality chemicals manufacturers in India have built exactly this capability, offering everything from standard catalogue compounds to fully customised synthesis at research and commercial scale. The country's leading pharma hubs in Hyderabad, Pune, Mumbai, and Bengaluru are already benefiting from this domestic sourcing shift. Speciality chemicals companies operating in India now provide end-to-end support including CoA, MSDS, HPLC data, and regulatory documentation aligned with international standards.

Chemical Sourcing for R&D Labs from India's Speciality Chemicals Industry 

Global pharmaceutical companies, biotechnology firms, and research institutions are increasingly turning to India for chemical sourcing for R&D labs. India's well-established speciality chemicals ecosystem offers high-purity compounds, flexible order quantities, and full regulatory compliance across ISO, GMP, and cGLP frameworks. The country's research-grade chemical supply chain spans major hubs including Hyderabad, Bengaluru, Pune, and Mumbai, ensuring reliable procurement for both early-stage and commercial-scale needs.

With speciality chemicals companies offering custom synthesis, analytical services, and end-to-end supply chain support, India has become a one-stop sourcing partner for gloal R&D. Cost-effective pricing, backed by stringent quality benchmarks, makes India a preferred destination for research-grade procurement.  

Organic Process Chemistry Powering Contract Research and Development in Specialty Chemicals 

For specialty chemical companies and pharmaceutical manufacturers, chemistry is the foundation upon which every successful development program is built. Organic process chemistry plays a defining role in how active ingredients and complex molecules are developed, optimized, and reliably scaled from laboratory-stage research into commercially viable production processes that meet regulatory and quality expectations. 

Contract research and development in the chemical sciences depends heavily on proven expertise in synthetic route development, process optimization, reaction hazard assessment, impurity profiling, and rigorous analytical method validation. Companies that outsource these highly specialized activities gain direct access to dedicated laboratories and experienced process chemists who can compress development timelines that would otherwise require years of sustained internal effort. 

Process chemistry services typically encompass route scouting, reaction optimization, solvent and reagent selection, scale-up engineering support, and structured technology transfer to downstream manufacturing partners. For companies advancing new molecular entities or improving existing synthesis routes, these services represent a high-value investment that delivers consistent returns throughout the product lifecycle and into commercial production. 

The growing decision to outsource chemistry research is driven by the simultaneous need for speed and deep specialization. SARA Research & Development Centre (SRDC) provides targeted chemistry and process development support exactly where and when it is needed, helping specialty chemical and pharmaceutical companies move forward without the overhead of maintaining fully staffed specialist teams internally. 

2 4 6 Tribromobenzene and 1 3 5 Tribromo Benzene: Key Intermediates in High-Performance Specialty Chemical Synthesis 

1,3,5-Tribromobenzene is a symmetrically structured halogenated aromatic compound widely used in pharmaceutical, agrochemical, and material science industries. Known in chemical databases as 1 3 5 tribromo benzene, this compound features three bromine atoms at alternating positions on the benzene ring, offering exceptional chemical stability and multiple reactive sites for selective functionalization. 

Its symmetric structure supports the synthesis of complex organic molecules through well-established cross-coupling reactions, including Suzuki and Negishi couplings. These reactions are central to building the molecular frameworks needed in drug development, organic semiconductor research, and specialty intermediate production. 

Procurement teams and research departments across India consistently source this compound from quality-certified manufacturers who meet international purity standards. The compound is produced at reagent-grade purity of 98-99%, suitable for both laboratory-scale investigation and large-scale industrial manufacturing. 

The demand for high performance heterocyclic compounds continues to grow across pharmaceutical, materials science, and specialty chemical industries. Among these advanced intermediates, phenyl-phenanthridine has gained significant importance due to its stable aromatic framework and versatility in complex organic synthesis. 

This article explores the applications, synthesis pathways, supplier selection criteria, and related specialty intermediates relevant to industrial buyers and research laboratories. 

What Is Phenyl-Phenanthridine and Where Is It Used 

Phenyl-phenanthridine belongs to the phenanthridine family of nitrogen containing polycyclic aromatic compounds. Its rigid aromatic core and extended conjugation make it highly useful in precision driven synthesis. 

Key Applications 

Pharmaceutical intermediates  The compound is frequently used in the synthesis of bioactive molecules and heterocyclic drug candidates. 

Fine chemical manufacturing  It serves as a precursor for functionalized aromatic systems used in advanced research. 

Organic electronics and materials  Its conjugated structure makes it relevant in the development of optoelectronic materials and specialty polymers. 

Research and laboratory scale synthesis  Academic and industrial laboratories rely on it for cross coupling reactions, ring construction, and derivatization processes. 

Due to its specialized applications, sourcing from a reliable phenyl-phenanthridine supplier is essential to ensure purity, batch consistency, and regulatory compliance. 

Synthesis Methods and Process Considerations 

The synthesis of phenyl-phenanthridine generally involves cyclization and coupling reactions using substituted aromatic precursors. Common strategies include: 

1. Palladium Catalyzed Cross Coupling 

Modern synthetic routes often utilize palladium catalysis to construct the heterocyclic core. This approach provides high yield and structural precision. 

2. Intramolecular Cyclization Reactions 

Controlled cyclization reactions are used to form the phenanthridine backbone under optimized reaction conditions. 

3. Industrial Scale Adaptation 

For commercial production, process parameters such as solvent selection, temperature control, purification strategy, and waste management are carefully optimized. High purity output and minimal impurity profile are critical in pharmaceutical and specialty applications. 

Quality manufacturers typically offer: 

Custom synthesis services 

Process optimization and scale up support 

Analytical testing including HPLC and GC 

Bulk supply and contract manufacturing 

Documentation support for industrial buyers 

Selecting a supplier with technical expertise ensures reproducibility and regulatory readiness. 

Role of Specialty Aromatic Intermediates in Advanced Chemistry 

In complex synthesis workflows, aromatic intermediates often work in combination. For example, 1 3 5 triisopropylbenzene plays an important role in specialized industrial processes. 

1,3,5-Triisopropylbenzene is a specialty aromatic hydrocarbon with the molecular formula C₁₅H₂₄ and CAS number 717-74-8. It consists of a benzene ring substituted with three isopropyl groups at the 1, 3, and 5 positions, resulting in a symmetrical and sterically bulky molecular structure. This structural configuration provides enhanced thermal stability, chemical resistance, and controlled reactivity, making it suitable for advanced organic synthesis. The compound is typically available as a clear, colorless liquid that is insoluble in water but soluble in most organic solvents. With a relatively high boiling point and stable physical properties under normal storage conditions, it is well suited for industrial handling and large scale chemical processing. 

In industrial applications, 1,3,5-triisopropylbenzene is primarily used as an intermediate in the production of specialty chemicals and functionalized aromatic derivatives. It is commonly involved in the synthesis of sulfonated compounds, performance additives, and other advanced organic intermediates where steric bulk and structural stability are important. Its properties also make it relevant in the development of polymers, specialty resins, coatings, and fine chemical formulations.

The target audience for this compound includes specialty chemical manufacturers, pharmaceutical and fine chemical producers, polymer and materials science companies, research laboratories, and bulk chemical distributors seeking high purity aromatic building blocks for precision driven applications. Overall, 1,3,5-triisopropylbenzene serves as a reliable and versatile intermediate for industries focused on innovation, quality, and consistent performance in chemical synthesis. 

When integrated into broader synthesis strategies, intermediates like phenyl-phenanthridine and 1 3 5 triisopropylbenzene contribute to performance driven formulations and advanced research pipelines. 

How to Choose the Right Supplier 

Choosing the right phenyl-phenanthridine supplier requires a structured evaluation process. 

1. Purity Standards 

Verify assay percentage, impurity profile, and analytical data. Reputable suppliers provide COA and batch traceability. 

2. Manufacturing Capability 

Ensure the supplier can handle small research quantities as well as bulk industrial volumes. 

3. Custom Synthesis Expertise 

For specialized derivatives, custom synthesis capability is essential. 

4. Regulatory and Documentation Support 

Industries such as pharmaceuticals require detailed documentation, stability data, and technical support. 

5. Supply Chain Reliability 

Timely delivery and consistent stock availability reduce production downtime. 

Reliable manufacturers typically offer contract manufacturing, scale up support, R and D collaboration, and quality assurance services to meet evolving industry needs. 

Conclusion 

The growing demand for advanced heterocyclic intermediates highlights the importance of sourcing high quality phenyl-phenanthridine from a technically competent manufacturer. From pharmaceutical development to specialty material synthesis, this compound plays a crucial role in modern chemical innovation. 

Businesses seeking reliable supply, custom synthesis services, and industrial scale manufacturing support are encouraged to contact SARA Research & Development Centre (SRDC) for professional assistance and tailored solutions. 

Frequently Asked Questions 

What industries use phenyl-phenanthridine? 

It is primarily used in pharmaceuticals, fine chemicals, materials science, and advanced research laboratories. 

Why is supplier quality important? 

Purity and consistency directly impact reaction yield, product stability, and regulatory compliance. 

Can it be supplied in bulk quantities? 

Yes, established manufacturers provide both research scale and commercial scale quantities depending on client requirements. 

What documents should a supplier provide? 

A Certificate of Analysis, safety data sheet, and batch traceability documentation are standard requirements. 

How does it compare to other aromatic intermediates? 

DNA intercalators are specialized molecules widely used in molecular biology, biochemistry, and pharmaceutical research. They have a unique ability to insert themselves between the base pairs of DNA, altering the structure and function of nucleic acids. This property makes them valuable tools in gene research, DNA staining, anticancer studies, and molecular diagnostics. 

For laboratories, universities, and biotech companies, sourcing high-quality DNA intercalator chemicals supplier is critical to ensure purity, consistency, and research reproducibility. A dependable supplier also provides technical guidance, regulatory compliance, and quality assurance for safe laboratory handling. 

What Are DNA Intercalator Chemicals? 

DNA intercalators are planar, aromatic compounds that slide between the stacked base pairs of DNA. This intercalation process causes the DNA helix to stretch and unwind slightly, influencing replication, transcription, and protein interactions. 

Common examples of DNA intercalators include: 

Ethidium Bromide – widely used as a DNA stain in gel electrophoresis. 

Acridine Orange – used for staining nucleic acids in fluorescence microscopy. 

Doxorubicin – a chemotherapeutic agent that intercalates into DNA, inhibiting cancer cell proliferation. 

Actinomycin D – used in molecular biology and research for transcription studies. 

These chemicals are invaluable for diagnostic assays, molecular cloning, fluorescence studies, and anticancer research, but require proper handling and sourcing from certified suppliers. 

Why Choosing a Reliable DNA Intercalator Chemicals Supplier Matters 

The quality and reliability of DNA intercalator chemicals directly impact research outcomes and experimental reproducibility. Here’s why sourcing from a trusted supplier is essential: 

High Purity – Impurities in intercalators can affect binding specificity and fluorescence intensity, compromising experimental results. 

Consistent Quality – Reproducible research requires chemicals with consistent physical and chemical properties. 

Regulatory Compliance – Suppliers adhering to international standards ensure safe handling, labeling, and transportation of hazardous chemicals. 

Technical Support – Experienced suppliers provide guidance on safe usage, storage conditions, and experimental protocols. 

Global Shipping – Reliable suppliers can deliver high-quality chemicals across different regions while complying with customs and safety regulations. 

Applications of DNA Intercalator Chemicals 

DNA intercalator chemicals are used across multiple research and industrial applications: 

1. Molecular Biology and Genetics 

Intercalators are routinely used in DNA staining, gel electrophoresis, and fluorescence imaging to visualize nucleic acids. Their ability to bind specifically to DNA enables precise detection and quantification. 

2. Pharmaceutical Research 

Many intercalators, such as doxorubicin and actinomycin D, serve as anticancer agents. Researchers study their mechanisms to develop new therapeutics and understand drug-DNA interactions. 

3. Biochemical Assays 

Intercalators are used in DNA-binding assays, mutation analysis, and transcription studies. Their fluorescence properties allow sensitive detection of nucleic acids in complex biological samples. 

4. Diagnostic Tools 

Certain DNA intercalators are utilized in molecular diagnostics, such as detecting genetic mutations or viral DNA, enabling early disease detection and monitoring. 

Factors to Consider When Selecting a Supplier 

When choosing a DNA intercalator chemicals supplier, laboratories and biotech firms should evaluate: 

Certification and Compliance – Ensure the supplier meets ISO, GMP, or other relevant standards. 

Product Range – A broad portfolio allows researchers to access multiple intercalators and related reagents from one source. 

Documentation – Certificates of analysis (CoA) and safety data sheets (SDS) are critical for lab safety and regulatory compliance. 

Storage and Shipping Conditions – Proper handling ensures chemical stability and longevity. 

Customer Support – Supplier expertise in applications and troubleshooting enhances research efficiency. 

Safety Considerations in Handling DNA Intercalators 

DNA intercalator chemicals are often mutagenic or cytotoxic, and handling requires strict laboratory safety protocols: 

Use gloves, lab coats, and eye protection. 

Work under a fume hood when preparing solutions. 

Dispose of waste according to local regulatory guidelines. 

Store chemicals in cool, dry, and dark conditions to maintain stability. 

Reliable suppliers often provide comprehensive safety data and usage instructions, reducing risk during experiments. 

Why Partnering with a Professional Supplier Accelerates Research 

A professional DNA intercalator chemicals supplier offers more than just the product—they provide technical expertise, regulatory guidance, and high-quality reagents that enable laboratories to: 

Achieve reproducible and reliable results. 

Minimize time lost due to substandard reagents. 

Ensure compliance with local and international safety standards. 

Focus on core research objectives without worrying about supply chain disruptions. 

Conclusion 

DNA intercalator chemicals are indispensable tools in modern molecular biology, diagnostics, and pharmaceutical research. Partnering with a trusted and reliable supplier ensures that your laboratory receives high-quality, pure, and compliant reagents, enabling accurate results, regulatory compliance, and safe handling.