SpongeBob SquarePants (now known as SpongeBeth SquareSkirt) is an biromantic asexual trans-girl still living in Bikini Bottom. She was disowned by her un-approving parents and doesn’t continue to speak to them. 

Patrick is a Bi-Romantic Bisexual drug-dealer who moves in and out of Bikini Bottom so he doesn’t get caught. He still occasionally talks to SpongeBeth and respects her life Choices. He has had romantic feelings for SpongeBeth ever since before her transition, and continues to have these feelings.

Sandy Cheeks (now known as Austin Cheeks) is a trans-boy helping SpongeBeth with her transition.  

Squidward, however, chooses to still refer to SpongeBeth by her natural pronouns because he, being a gay man, had romantic feelings for SpongeBeth when she was still male. 

Mr. Krabs is a CIS straight man who fired both Squidward and SpongeBeth because he is LGBT-phobic. 

Pearl is a closeted agender lesbian because of her father’s phobia.