Multiple Alignment
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Multiple Alignment

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Dynamic Programming
Interval Scheduling(Binary Choice)
- Greedy can be used if all weights are 1
- Sort by finishing time: O(nlogn)
- Computing: O(n) –if Memoization used
- OPT(j) = 0(if j=2) / otherwise max {vj + Opt(p(j)), OPT(j-1)}
Segmented Least Squares(Multi-way choice)
- O(n^3) – can be improved to O(n^2) by pre-computing various statistics
- OPT(j) = 0 if j=0 / min {e(i,j) + c + OPT(i-1)} if 1<=i<=j
- OPT(j): minimum cost for points / e(i,j): minimum sum of squares for points
Knapsack(Adding a new variable)
- OPT(i, w) = 0 if i=0 / OPT(i-1, w) if wi > w / max {OPT(i-1, w) + OPT(i-1,w-wi)}
- O(nW) – not polynomial in input size(Pseudo-polynomial)
- NP-complete
Sequence Alignment
- Gap penalty ;(delta) mismatch penalty (alpha)
- OPT(i,j) = jd if i=0 / min(axiyi + OPT(i-1, j-1), d + OPT(i-1, j), d + OPT(i, j-1) / id if j=0
- O(mn) time and space (m, n: length of each string) -> space can be reduced to O(m+n) by divide-and-conquer