Hello, I really love this blog!!! I'm writing a story about a zombie apocalypse but setting at a time where there's already a vaccine. However, the vaccine causes schizophrenia as a side effect. I wanted to know how would a person act of they didn't know they had schizophrenia. Also, what are the symptoms of severe schizophrenia? Lastly, what are some of the medications for schizophrenia, I want to have a scene where the MC has to remake some of the meds to help another immune character.
There are a lot of questions here, so Iām going to go one by one.
I wanted to know how would a person act of they didnāt know they had schizophrenia.Ā
Thereās something calledĀ āanosognosiaā thatĀ affects about 50% ofĀ people diagnosed with schizophrenia. While itās a medical term, when used in a psychology context, it basically means that the character lacks awareness of their mental illness or is incapable of understanding that they have one.
So not knowing they had schizophrenia would not make their behavior significantly different from those who naturally have schizophrenia.
As for the symptoms of schizophrenia, check out my post here for the criteria.
Iām not 100% comfortable answering the meds question, but I am going to take Psychopharm in the fall - Iāll do posts on it then!
But there is one other thing Iād like to address:
I want to have a scene where the MC has to remake some of the meds to help another immune character.
This is going to be very, very hard for your MC to do. Antipsychotics are very complicated.
I asked Z and J fromĀ @scriptchemist to help explain some of the things you have to consider here:
1) Precursors. What are they starting with? If you have the appropriate precursors and just need to put a few pieces together and/or tweak a few bonds, that is a very different story than if all they have is a can of burning gasoline and some vinegar (also, sometimes even ājust a few bondsā is ridiculously difficult with several sub-steps but I digress). For example, Iām assuming they donāt have halogenated nitro arene just lying around in their kitchen?Ā
2) Equipment and other reagents. A āstandardā organic/med chem lab has a whole host of specialized equipment and reagents, the latter of which isnāt specific to this synthesis but so broadly used in so many procedures they have them on hand, such as solvents, hot plates/cold baths, reducing agents, etc. Iām sure there must be some way of jerry-rigging a reflux condenser but Iām having a hard time thinking of it right now.Ā
3) Yield/purity. Really important for drugs. That importance increases exponentially the further you are from your finished final product as you have to purify your intermediates before proceeding to the next step. My very first search for clozapine synthesis involves four steps from a particular arene, though there are other variations. Thatās four steps of equipment, reagents, and purification.Ā
4) Dosage. Medicine is very precise in dosage and how that dosage is delivered for very, very good reasons. 5 mg of actual drug can be wrapped up in a 50 mg package with excipients to control the delivery; you donāt want to take it neat. And even if the character can somehow get a batch of 100% pure clozapine and appropriately store it, can they accurately parcel out the dosage? If one is supposed to take 10 mg of drug and accidentally takes 100mgā¦well.Ā
While I am certain that some existing person could actually do this, the experience, equipment, and precursors are going to be impossible hurdles for almost everyone. Ā Those are rather complicated syntheses, and a huge amount can go wrong very quickly. Ā Even with the correct precursors and a full laboratory, I wouldnāt trust myself to get the right product in sufficient purity to actually use as a medicine.Ā
TL;DR: Itās really not feasible to synthesize antipsychotics in your kitchen.
Since you describe the situation as a zombie apocalypse, Iād honestly recommend that your character raid an abandoned pharmacy or hospital to get the medications (though I imagine theyād be in high demand).
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