High-Resolution RNA-Sequencing Enables Detection of Disease at Its Earliest Stages
High-Resolution RNA-Sequencing Enables Detection of Disease at Its Earliest Stages
Published in the scientific journal, Nature Methods, the study was performed by researchers from KTH Royal Institute of Technology and the Broad Institute of MIT and Harvard.
The technology builds on transcriptomics, or the mapping of the cell’s molecular fingerprints. RNA-sequencing provides a tool for studying different functions within tissues but the molecular profile only reveals so much.…
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The human body is made up of about 100 trillion cells, but not all these cells are ‘real’ human cells. About one-tenth, in fact, are tiny organisms like bacteria, fungi, and viruses that live within us and on us. These organisms are collectively known as microbes and they play an essential role in human health and disease. Yet, exactly how they function and are affected by environmental changes is not entirely understood, and even less is known about how the [more...]
In recent years, high-throughput sequencing technologies have become essential for studying genomics, epigenomics, and transcriptomics. As well, there has been increasing interest in exploring RNA modifications and their critical role in post-transcriptional gene regulation. We’ve previously reported on epigenetic studies where RNA methylation was found to be involved in memory formation and child development and how the most abundant modification, 6-methyladenosine (m6A), is being researched for its participation in DNA damage responseamong other things. We’ve also highlighted epigenetic studies on the microbiome and how gut bacteria impacts certain epigenetic marks. The findings from this study, it seems, enhances the epigenetic researcher’s toolbox, putting RNA and the microbiome in the spotlight for further exploration.
