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Chemogenetics have dramatically transformed how biologists deconstruct the involvement of G protein-coupled receptors (GPCRs) in a myriad of physiological and translational settings

Here we highlight a specific chemogenetic application that extends the utility of the concept ofRASSLs (receptors activated solely by synthetic ligands)

DREADDs are now used ubiquitously to modulate GPCR activity noninvasively in vivo.

#DREADD #RASSL #G protein-coupled receptors #GPCRs #technique