#phenformin

Nano packages for anti-cancer drug delivery

Cancer stem cells are resistant to chemotherapy and consequently tend to remain in the body even after a course of treatment has finished, where they can often trigger cancer recurrence or metastasis. A new study by researchers from the A*STAR Institute of Bioengineering and Nanotechnology has found that using nanoparticles to deliver an anti-cancer drug that simultaneously kills cancer cells…

Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases.

Phenformin was discovered in 1957 by Ungar, Freedman and Seymour Shapiro, working for the US Vitamin Corporation. Clinical trials begun in 1958 showed it to be effective, but with gastrointestinal side effects.[1]

(Source Wikipidea)

Other Sources:

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http://www.sigmaaldrich.com/catalog/product/fluka/p7045?lang=en&region=RO

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http://care.diabetesjournals.org/content/29/4/950.full

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https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=8249

http://www.cnn.com/2010/HEALTH/01/23/fake.diet.drug/index.html