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Conotoxin
This is an image of conotoxin and an inset of how it affects a voltage-gated calcium channel (VGCC). Conotoxin is a peptide toxin created by a tropical marine snail (Conus victoriae). Aside from VGCCs, the toxin also targets voltage-gated sodium channels, voltage-gated potassium channels, and nicotinic acetylcholine receptors. Conotoxins are being explored as an option for pain-relief therapy.
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PDBe
PDB entries 3wvg, 3wvh, 3wvi, 3wvk and 3wvp
HindIII is a very commonly used restriction endonuclease in molecular biology, recognising the palindromic DNA sequence AACGTT and cleaving between the two adenosine residues. Metal ions are required at the active site for the enzyme to function and previous studies have shown two are present at the active site. It has been unclear however whether one or both ions were needed for catalysis, but these structures shed light on this.
The work is descibed by Kawamura et al. in Acta Cryst D. DOI:10.1107/S1399004714025188
