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Sovaldi: Why $1,000 a pill?
The good news: Sovaldi, a new drug that treats hepatitis C, has a cure rate as high as 90% for a disease that afflicts 3 million people in the United States, and with fewer complications than previous treatments.
The bad news: Sovaldi costs $1,000 a pill.
Full story in USA Today.
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PUSH, PULL, POOL: Accelerating Innovation and Access to Medicines for Tuberculosis
Tuberculosis (TB) mainly affects low- and middle- income countries with 95% of cases occurring there. 1.3 million people were killed by the disease in 2012 and there were 8.6 million new cases requiring treatment. With the advent of new diagnostics like GeneXpert the confirmed numbers of multidrug-resistant (MDR) TB cases are rising and programmes are unable to cope - 16,000 patients diagnosed with MDR-TB in 2012 did not receive treatment. And about 80% of those estimated to have MDR-TB are not even diagnosed.
MDR-TB treatment is particularly difficult, because it is long—two years of treatment including eight months of daily injections and a total of more than 14,600 pills to swallow—and because many of the medicines used have toxic side effects such as deafness, psychosis and severe nausea. Moreover, the success rate is unacceptably low with only 48% of patients being cured, and costs can be very high. For 9% of global cases with extremely drug-resistant TB (XDR-TB) treatment is even longer, more expensive and the success rate is even lower at only 13%.
Full Doctors Without Borders overview of their Push, Pull, Pool Program here:
http://www.msfaccess.org/our-work/driving-medical-innovation/article/2157
That’s the crucial part about being open. It’s that you don’t have to define your team in advance. It’s very thrilling.
Matthew Todd, founder of Open Source Malaria
We do the majority of our work in rural and tribal areas. There, the absence of treatment for things like this is death.
--R. Venkat of Tata Trusts @TataCompanies
Why West African governments are struggling in response to Ebola
The Washington Post: "The worst-ever Ebola epidemic continues to unfold in West Africa, with no sign that it will be under control anytime soon. As of Saturday, [July 12, 2014], there have been 397 deaths among the 706 confirmed cases (a 56 percent fatality rate) since reports of Ebola cases in West Africa began to emerge in March. The first cases of the epidemic were reported in Guinea, but additional cases were later reported in neighboring Liberia and then Sierra Leone. All three countries have poor health infrastructure and are struggling alongside international actors to stop Ebola’s spread."
and
"Ebola is an infectious virus that often results in death. Anywhere between 2 and 21 days after infection, patients’ early symptoms will include fever, weakness, muscle pain, headaches and a sore throat. The disease progresses to vomiting, diarrhea, impaired organ function and bleeding. There is no vaccine to protect against Ebola, and there are no specific treatments beyond managing symptoms of those infected. The primary goal in responding to Ebola, then, is to stop its spread by isolating those suspected of infection and raising awareness in affected communities on how to protect against infection."
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He found, to his surprise, that there were pharmacologists coming out of the woodwork.
Bernard Munos, telling a story about someone who was trying to repurpose a drug via crowdsouring (NIH NCATS rescue program for orphan drugs).
Open Source Pharma Conference / Rockefeller Foundation Bellagio Center / July 2014
Sixth Law of open source research
An open project is bigger than, and is not owned by, any given lab.
http://openwetware.org/wiki/Open_Source_Research
Fifth Law of open source research
Public discussion is much more valuable than private email.
http://openwetware.org/wiki/Open_Source_Research
