Gojo being raised as a weapon first, person second (maybe almost never). Isolated with people who were afraid of him, sometimes even worshiping him because his own existence tipped the balance and that means something. He can get whatever he wants by just asking, except actually emotional bonds. Being told he's the strongest, strong enough to topple a Nation. Only actually ever making friends that weren't that scared of him when joining Jujutsu High.

Then there's Saiki, someone born with powers and kept getting powers that would be able to destroy the whole world. Being subject to humanities thoughts, worst and best. However instead of fear, his parents loved him, cherished him. His brother was jealous of him, so much to the point of getting masochistic with it. He had a childhood friend before getting into timeline trouble and ended up wiping his memory. Despite that, he makes friends (begrudgingly) during his high school days.