#nebiolab

"Based on cellular function and activity, in-vitro cytotoxicity and cell viability assays for drug discovery and fundamental research. "

·         Cytotoxicity assays are designed to assess the ability of specific drug compounds to destroy an organism's healthy cells.

·         Cytotoxic compounds can cause either accidental (necrosis) or programmed cell death (referred to as apoptosis).

·         Cytotoxicity assays are used to evaluate the safety profile of a drug candidate during the nonclinical and clinical research phases of drug discovery and development.

“In-vitro biochemical assay for detecting, quantifying, and studying the binding or activity of biomolecules such as enzymes. “

The PK PD analysis study connects drug exposure to therapeutic effect measures so that drug developers can better understand the relationships between exposure, efficacy, and toxicity.

As a result, the PK PD assay and data analysis results are critical for any ECTD submission.

Non-compartmental analysis (NCA) is typically used to calculate pharmacokinetics (PK) parameters after determining test article concentrations in clinical or preclinical study samples.

When discussing exposure, activity, or toxicity, the area under the curve (AUC) and maximum concentration (Cmax, or C0 for an IV dose) are generally accepted as the most critical PK parameters.

To identify, separate, and quantify drug and metabolites in biological fluids, our scientists employ effective method development, transfer, set-up, and validation techniques.We offer the method-based services listed below.

Development of Methods

• Reverse engineer and quickly switch between species/matrices • Provide equipment recommendations based on molecule and sensitivity (LC-MS vs. ELISA) • Improve sample preparation and instrument settings. • Iterate according to the target curve range, Cmax, Tmax, and AUC.