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Treatment for adults to treat the chronic pain can be an immediate-release tablet in the following format: The initial dose consists of 25 mg per day. Then titrate by increments of 25 mg in every 3 days to until reaching a daily dosage of 4 times 25 mg. For the next, every 3 days you can increase each dosage by 50 mg until you reach the dosage of 50 mg in a day.

Usually 50-100 mg can be consumed when needed every 4-6 hours, but not more than 400 mg in a day.

Guidelines for extended-release tablets are very different, as you only consume one dose in a day: after the initial single 100 mg dose the first day, you can increase by 100 mg every five days until you get the maximum amount of 300 mg dosage in your body.

Doses are adjusted individually, depending on:

The type of the pain you are feeling or facing so often. For liver and renal conditions, that intake limits are lower.

Special populations: like as the children, geriatric patients, or the pregnant women

Type and severity of the pain: sometimes moderate, severe, or the chronic

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