#mitf

Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis. Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1).

Common carp

reddish

Inheritence: double recessive. (Carps - being allotetraploid fish - have four MITF paralogue gene, two mitfa and two mitfb. For this phenotype, both mitfa genes, all four copies need to lose function.)

image source

Japanese quail

silver

Inheritence: intermediate.

heterozygote and homozygote

Duck

white

black beak

Inheritence: white feather is recessive, black beak is dominant.

white feather, black beak

Mouse

brownish

black-eyed white

black and white spotting

cloudy-eye

microphtalmia (four mutations)

eyeless white

red-eyed white

spotted

vitiligo

white

Inheritence: white is intermediate, the rest are recessive to the wild type and intermediate to various degree with each other; certain allele combinations complement each other, and bring the phenotype closer to the wild type than either of the homozygotes.

(A) spotted/eyeless white, (B) spotted/spotted, (C) brownish/red-eyed white, (D) red-eyed white/red-eyed white, (E) eyeless white/microphtalmia, (F) white/spotted (G) red-eyed white/microphtalmia, (H) white/red-eyed white

(A) white/+ and white/white, (B) microphtalmia/microphtalmia, (C) white/microphtalmia, (D) white/eyeless white, (E) microphtalmia/microphtalmia and white/microphtalmia (oak ridge allele), (F) white/brownish and brownish/brownish (G) black and white spotting/black and white spotting, (H) white/black and white spotting

(A) spotted/spotted, (B) red-eyed white/spotted, (C) white/+, white/white, +/+, (D) brownish/spotted, (E) vitiligo/vitiligo (older behind), (F) red-eyed white/vitiligo, (G) white/spotted, (H) eyeless white/vitiligo, (I) eyeless white/spotted, (J) microphtalmia/vitiligo (older left), (K) red-eyed white/red-eyed white, (L) vitiligo/spotted, (M) microphtalmia/spotted, (N) black eyed white/black eyed white, (O) white/microphtalmia, (P) microphtalmia/microphtalmia and +/+

image sources: 1, 2, 3, 4, 5

Syrian hamster

microphthalmia

Inheritence: slightly intermediate.

heterozygote, wild type, homozygote

Dog

white spotting

Inheritence: additive.

image source

American mink

Hedlund

Inheritence: intermediate.

homozygote, heterozygote

Cattle

white spotting (holstein/simmental)

white spotting (brown swiss)

splotchy face/specled spots/black socks

near-white (Waardenburg syndrome 2A)

dominant white (with bilateral deafness)

glass-eyed albino

Inheritence: naturally dominant white is dominant, as is glass-eyed albino and the brown swiss allele (and i mean real dominance - in general, homozygotes DO NOT have more white than heterozygotes), the holstein is undetermined. The near-white pattern and the white microphtalmia are unknown: was both found de novo in one single animal respectively, who was heterozygous in both cases.

simmental, brown swiss, near-white, splotchy face, speckled spots, black spots, dominant white, glass-eyed albino, microphthalmia

Water buffalo

white spotting (two mutations)

Inheritence: probably lethal is homozygotes.

identified carrier of the first mutation, unidentified but phenotypically similar to a carrier of the second mutation

Horse

splashed white (SW1, SW3, SW5-9)

macchiato

white

Inheritence: probably mostly lethal in homozygotes and compound heterozygotes; the exception is SW1 which gives full whites with other alleles and more extensive white spotting with itself.

this week’s illustration, for chapter 3 c:

Cuando alguien a quien quieres desaparece.

Tu mundo se detiene.

Porque para ti es imposible habitar el mundo sin poder ver a esa persona nunca más.

Sin poder contarle todo lo bueno y todo lo malo que te suceda.

Sin poder decir su nombre y que te responda.

Sin saber de ella ni que ella sepa de ti.

Nada.

Cuando alguien a quien quieres se muere.

El mundo te duele.

Te duele su belleza y te duele la rutina.

Te duele que la gente siga viendo anuncios y haciendo planes y enamorándose y tirándose por toboganes.

Te duelen las risas.

Porque tú estás tan triste que la alegría ajena te quema.

Cuando alguien a quien quieres se va.

Te quedas tú.

Y sientes la líquida soledad están en compañía.

Y alguien perfora las palabras para vaciarlas de su sentido.

Y el mar es una pecera.

Y los espejos cristales.

Y no hay consuelo.

Porque te dicen que el tiempo lo cura todo.

Pero tú lo que menos quieres es que pase el tiempo.

Porque cuanto más te alejas de esa última vez que viste a esa persona.

Más se borra su cara, su voz, su olor, su todo.

Tú lo que quieres es parar el tiempo con hacha y correr hacia detrás.

Y darle un último abrazo y besar y abrazar y tocar y mirar y fijarte y retener y decir lo que nunca dijiste por vergüenza o por pudor o porque no si quiera lo sabías y ahora ya lo sabes.

Cuando a alguien a quien quieres se le acaba la vida.

Te arrepientes de no haber valorado los instantes.

De haber discutido por tonterías.

De haber querido tener la razón.

De haberlo hecho todo tan difícil siendo tan simple.

Cuando alguien a quien quieres no puede seguir siendo.

o que te toca a ti.

Es existir más.

Es vivir fuerte.

Porque lo único que queda aquí de la personas que quisiste es tu sentimiento sobre esa persona.

Es tu querer.

Y cada vez que celebras, que maldices, que respiras, que se te pincha una rueda, que descubres una canción o que pruebas algo de comer.

Estás celebrando a ese alguien.

Permitiendo que resplandezca en el brillo de tus ojos.

Como la luz de todas esas estrellas.

Que aunque sigan en el Universo.

Ya no están.

(ROY Galán)

Never has a game made me consider literal cannibalism as romantic.

Or bees and tentacles.

Honestly buff werewolf bf always seemed attractive

in about three weeks i’m headed to israel. i will be living in ramla for 10 months, working in the local school system (i’m not sure exactly where yet) teaching english as a foreign language to kids (ages 7-13, again i’m not sure exactly)

i am firmly an antizionist and me living there for 10 months is not going to change that. i plan on doing as much pro-palestine work as i can while i’m there, though sadly i can’t go into the settlements or any “risky” areas to do direct hands-on work (ie the west bank, gaza, potentially parts of jerusalem, etc) or i will be sent home and i’ll owe my program about $15,000, since all but a very little bit of the program cost is being funded by various grant organizations. (that is not money i have.)

so like i said i’ll be working with kids, in a very diverse, low-income area. i’ll also be living away from my family for the first time in my life, which is going to be good for me in a way that i can’t really put into words -- my home life over the past decade or more has been fairly toxic at best and downright abusive at worst, so while it’s selfish of me to be thinking of myself in this way, this is something that will be very good for my mental health (as well as a way to get a fresh start, and to try to learn to be more outgoing, to work through my anxiety, etc.)

regardless, if me being there makes you uncomfortable in any way, please know that i understand, and if you feel like you need to unfollow me please do so. i will be tagging all israel- and program-related things from now on as “mitf” (the name of the program) so you can also blacklist accordingly if you don’t want to see it. so far i’m not entirely sure what to expect, so it’s hard to say exactly what i will be posting on here about it. and again, while i am firmly opposed to israel as a nation, i’m jewish. going there is going to (hopefully) provide a fulfilling religious experience for me. i’m lucky and privileged to have this opportunity, so again if seeing me discuss it will be too painful i understand if you need to unfollow.