#misfold

the morons of all time. can they kiss already

Publication date: Source:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Author(s): P. Hemachandra Reddy — ScienceDirect Publication: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Univ. of Delaware assistant professor David Colby is co-author of a paper in the Journal of Biological Chemistry that suggests protein misfolding may occur early in the development of Huntington’s disease. Huntington’s disease (HD) is one of several neurological diseases, such as Alzheimer’s disease or prion disease, associated with proteins that fold into abnormal structures. HD is characterized by progressive motor impairment, cognitive decline and behavioral abnormalities, and ultimately death. The researchers developed a novel technology, called an amyloid seeding assay (ASA), to detect the misfolded protein, huntingtin, in laboratory mice at 11 weeks of age, more sensitively than traditional histology methods that don’t reveal large inclusions until much later in the pathogenic process, about 78 weeks. Read more: http://www.laboratoryequipment.com/news-method-detects-misfolded-protein-earlier-040912.aspx